Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| glnA | gltA | BSU17460 | BSU18450 | Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism . It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia . Feedback-inhibited GlnA interacts with and regulates the activity of the transcriptional regulator TnrA During nitrogen limitation, TnrA is in its DNA- binding active state and turns on the transcription of genes required for nitrogen assimilation Under conditions of nitrogen exce [...] | Glutamate synthase (nadph) large chain; Belongs to the glutamate synthase family | 0.997 |
| glnA | gltB | BSU17460 | BSU18440 | Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism . It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia . Feedback-inhibited GlnA interacts with and regulates the activity of the transcriptional regulator TnrA During nitrogen limitation, TnrA is in its DNA- binding active state and turns on the transcription of genes required for nitrogen assimilation Under conditions of nitrogen exce [...] | Glutamate synthase [NADPH] small chain; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme | 0.993 |
| glnA | gudB | BSU17460 | BSU22960 | Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism . It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia . Feedback-inhibited GlnA interacts with and regulates the activity of the transcriptional regulator TnrA During nitrogen limitation, TnrA is in its DNA- binding active state and turns on the transcription of genes required for nitrogen assimilation Under conditions of nitrogen exce [...] | Cryptic catabolic nad-specific glutamate dehydrogenase gudb; GudB seems to be intrinsically inactive, however spontaneous mutations removing a 9-bp direct repeat within the wild-type gudB sequence activated the GudB protein and allowed more-efficient utilization of amino acids of the glutamate family. This insertion presumably causes severe destabilization of the fold of the protein, leading to an inactive enzyme that is very quickly degraded. The cryptic GudB serves as a buffer that may compensate for mutations in the rocG gene and that can also be decryptified for the utilization of [...] | 0.960 |
| glnA | purF | BSU17460 | BSU06490 | Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism . It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia . Feedback-inhibited GlnA interacts with and regulates the activity of the transcriptional regulator TnrA During nitrogen limitation, TnrA is in its DNA- binding active state and turns on the transcription of genes required for nitrogen assimilation Under conditions of nitrogen exce [...] | Glutamine phosphoribosylpyrophosphate amidotransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine | 0.946 |
| glnA | putC | BSU17460 | BSU03210 | Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism . It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia . Feedback-inhibited GlnA interacts with and regulates the activity of the transcriptional regulator TnrA During nitrogen limitation, TnrA is in its DNA- binding active state and turns on the transcription of genes required for nitrogen assimilation Under conditions of nitrogen exce [...] | 1-pyrroline-5-carboxylate dehydrogenase; Important for the use of proline as a sole carbon and energy source or a sole nitrogen source | 0.918 |
| glnA | pyrAA | BSU17460 | BSU15510 | Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism . It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia . Feedback-inhibited GlnA interacts with and regulates the activity of the transcriptional regulator TnrA During nitrogen limitation, TnrA is in its DNA- binding active state and turns on the transcription of genes required for nitrogen assimilation Under conditions of nitrogen exce [...] | Pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit); Carbamoyl-phosphate synthase pyrimidine-specific small chain; Evidence 2b: Function of strongly homologous gene; Product type e : enzyme | 0.941 |
| glnA | rocA | BSU17460 | BSU37780 | Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism . It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia . Feedback-inhibited GlnA interacts with and regulates the activity of the transcriptional regulator TnrA During nitrogen limitation, TnrA is in its DNA- binding active state and turns on the transcription of genes required for nitrogen assimilation Under conditions of nitrogen exce [...] | 1-pyrroline-5-carboxylate dehydrogenase; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type e: enzyme | 0.939 |
| glnA | rocG | BSU17460 | BSU37790 | Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism . It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia . Feedback-inhibited GlnA interacts with and regulates the activity of the transcriptional regulator TnrA During nitrogen limitation, TnrA is in its DNA- binding active state and turns on the transcription of genes required for nitrogen assimilation Under conditions of nitrogen exce [...] | Catabolic nad-specific glutamate dehydrogenase rocg; Devoted to catabolic function of glutamate (and other amino acids of the glutamate family) utilization as sole nitrogen source. It is not involved in anabolic function of glutamate biosynthesis since B.subtilis possesses only one route of glutamate biosynthesis from ammonia, catalyzed by glutamate synthase. RocG is unable to utilize glutamate or glutamine as sole carbon source and to synthesize glutamate, but it is involved in the utilization of arginine, and proline as carbon or nitrogen source. The catabolic RocG is essential for c [...] | 0.990 |
| gltA | glnA | BSU18450 | BSU17460 | Glutamate synthase (nadph) large chain; Belongs to the glutamate synthase family | Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism . It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia . Feedback-inhibited GlnA interacts with and regulates the activity of the transcriptional regulator TnrA During nitrogen limitation, TnrA is in its DNA- binding active state and turns on the transcription of genes required for nitrogen assimilation Under conditions of nitrogen exce [...] | 0.997 |
| gltA | gltB | BSU18450 | BSU18440 | Glutamate synthase (nadph) large chain; Belongs to the glutamate synthase family | Glutamate synthase [NADPH] small chain; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme | 0.999 |
| gltA | gudB | BSU18450 | BSU22960 | Glutamate synthase (nadph) large chain; Belongs to the glutamate synthase family | Cryptic catabolic nad-specific glutamate dehydrogenase gudb; GudB seems to be intrinsically inactive, however spontaneous mutations removing a 9-bp direct repeat within the wild-type gudB sequence activated the GudB protein and allowed more-efficient utilization of amino acids of the glutamate family. This insertion presumably causes severe destabilization of the fold of the protein, leading to an inactive enzyme that is very quickly degraded. The cryptic GudB serves as a buffer that may compensate for mutations in the rocG gene and that can also be decryptified for the utilization of [...] | 0.996 |
| gltA | purF | BSU18450 | BSU06490 | Glutamate synthase (nadph) large chain; Belongs to the glutamate synthase family | Glutamine phosphoribosylpyrophosphate amidotransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine | 0.948 |
| gltA | putC | BSU18450 | BSU03210 | Glutamate synthase (nadph) large chain; Belongs to the glutamate synthase family | 1-pyrroline-5-carboxylate dehydrogenase; Important for the use of proline as a sole carbon and energy source or a sole nitrogen source | 0.938 |
| gltA | pyrAA | BSU18450 | BSU15510 | Glutamate synthase (nadph) large chain; Belongs to the glutamate synthase family | Pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit); Carbamoyl-phosphate synthase pyrimidine-specific small chain; Evidence 2b: Function of strongly homologous gene; Product type e : enzyme | 0.942 |
| gltA | pyrD | BSU18450 | BSU15540 | Glutamate synthase (nadph) large chain; Belongs to the glutamate synthase family | Dihydroorotate dehydrogenase (nad+) catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor | 0.599 |
| gltA | rocA | BSU18450 | BSU37780 | Glutamate synthase (nadph) large chain; Belongs to the glutamate synthase family | 1-pyrroline-5-carboxylate dehydrogenase; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type e: enzyme | 0.934 |
| gltA | rocG | BSU18450 | BSU37790 | Glutamate synthase (nadph) large chain; Belongs to the glutamate synthase family | Catabolic nad-specific glutamate dehydrogenase rocg; Devoted to catabolic function of glutamate (and other amino acids of the glutamate family) utilization as sole nitrogen source. It is not involved in anabolic function of glutamate biosynthesis since B.subtilis possesses only one route of glutamate biosynthesis from ammonia, catalyzed by glutamate synthase. RocG is unable to utilize glutamate or glutamine as sole carbon source and to synthesize glutamate, but it is involved in the utilization of arginine, and proline as carbon or nitrogen source. The catabolic RocG is essential for c [...] | 0.998 |
| gltB | glnA | BSU18440 | BSU17460 | Glutamate synthase [NADPH] small chain; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme | Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism . It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia . Feedback-inhibited GlnA interacts with and regulates the activity of the transcriptional regulator TnrA During nitrogen limitation, TnrA is in its DNA- binding active state and turns on the transcription of genes required for nitrogen assimilation Under conditions of nitrogen exce [...] | 0.993 |
| gltB | gltA | BSU18440 | BSU18450 | Glutamate synthase [NADPH] small chain; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme | Glutamate synthase (nadph) large chain; Belongs to the glutamate synthase family | 0.999 |
| gltB | gudB | BSU18440 | BSU22960 | Glutamate synthase [NADPH] small chain; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme | Cryptic catabolic nad-specific glutamate dehydrogenase gudb; GudB seems to be intrinsically inactive, however spontaneous mutations removing a 9-bp direct repeat within the wild-type gudB sequence activated the GudB protein and allowed more-efficient utilization of amino acids of the glutamate family. This insertion presumably causes severe destabilization of the fold of the protein, leading to an inactive enzyme that is very quickly degraded. The cryptic GudB serves as a buffer that may compensate for mutations in the rocG gene and that can also be decryptified for the utilization of [...] | 0.930 |
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