STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
proHPyrroline-5-carboxylate reductase 1; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline (297 aa)    
Predicted Functional Partners:
proJ
Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
 
 
 0.995
proA
Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate
 
 
 0.978
proB
Glutamate 5-kinase 1; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
 
 
 0.965
putC
1-pyrroline-5-carboxylate dehydrogenase; Important for the use of proline as a sole carbon and energy source or a sole nitrogen source
     
 0.927
rocA
1-pyrroline-5-carboxylate dehydrogenase; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type e: enzyme
     
 0.916
proG
Redundant pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
  
  
0.887
putB
Proline dehydrogenase 2; Converts proline to delta-1-pyrroline-5-carboxylate. Important for the use of proline as a sole carbon and energy source or a sole nitrogen source
   
 0.880
putM
Proline dehydrogenase 1; Converts proline to delta-1-pyrroline-5-carboxylate
   
 0.843
proI
Pyrroline-5-carboxylate reductase 2; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
  
  
0.835
guaA
Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP
  
  
 0.729
Your Current Organism:
Bacillus subtilis
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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