Transcriptional regulator (metals sensing ArsR-SmtB repressors family); Metal-responsive transcriptional regulator that represses transcription of the aseR-ydfA operon by binding specifically to its promoter. Binding of arsenite or antimonite causes the repressor to dissociate from the DNA.

Repressor of copper utilisation proteins; Copper-sensitive repressor that has a key role in copper homeostasis. Negatively regulates expression of the copZA operon and of ycnJ. In the absence of copper ions, binds with high affinity to the copZA promoter and represses the transcription. In the presence of copper ions, CsoR binds Cu(1+), which significantly decreases its DNA binding affinity and leads to the transcription of the genes.

Zn transporter; Couples the hydrolysis of ATP with the transport of zinc into the cell. Plays an important role in protecting cells against oxidative stress. ZosA-mediated zinc transport is required for post- transcriptional control of comK and competence development.

Copper efflux transcriptional regulator; Transcriptional activator of the copZA operon.

Transcriptional regulator (DtxR family); Central regulator of manganese homeostasis that regulates the expression of both manganese uptake and efflux systems. In the presence of high levels of manganese, it mediates repression of the manganese uptake systems MntH and MntABCD and activation of the efflux systems MneP and MneS. Binds with high affinity to the regulatory regions of its target genes. The manganese concentration required for activation of efflux is higher than that for repression of uptake ; Belongs to the DtxR/MntR family.

copper(I)-transporting ATPase; Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell. Does not seem to transport copper.

Transcriptional regulator (Fur family); Hydrogen and organic peroxide sensor. Represses the expression of a regulon of peroxide-inducible genes such as katA, ahpC, ahpF, the heme biosynthesis operon (hemAXCDBL), fur, perR, zosA and mrgA; Belongs to the Fur family.

Putative transcriptional regulator (MerR family); Transcriptional regulator involved in the response to aldehyde stress. Binds to the promoter region of the adhA-yraA operon, the yraC and its own promoter region; binding is unchanged in the presence of aldehydes.

Zinc metallochaperone with NTPase activity; May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc.