| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| clpC | clpE | BSU00860 | BSU13700 | Class III stress response-related ATPase, AAA+ superfamily; Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with MecA to negatively regulate comK; Belongs to the ClpA/ClpB family. ClpC subfamily. | ATP-dependent Clp protease (class III stress gene); ATPase essential both for efficient CtsR-dependent gene derepression during heat stress and for rerepression. Together with ClpP, degrades the global regulator CtsR after heat shock. Is also involved in disaggregation of heat-denatured proteins. Has thus a role in overall protein quality control in response to heat stress. | 0.649 |
| clpC | cotP | BSU00860 | BSU05550 | Class III stress response-related ATPase, AAA+ superfamily; Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with MecA to negatively regulate comK; Belongs to the ClpA/ClpB family. ClpC subfamily. | Spore coat protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor. | 0.661 |
| clpC | dnaK | BSU00860 | BSU25470 | Class III stress response-related ATPase, AAA+ superfamily; Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with MecA to negatively regulate comK; Belongs to the ClpA/ClpB family. ClpC subfamily. | Molecular chaperone; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.996 |
| clpC | yocM | BSU00860 | BSU19260 | Class III stress response-related ATPase, AAA+ superfamily; Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with MecA to negatively regulate comK; Belongs to the ClpA/ClpB family. ClpC subfamily. | Putative spore coat protein; Part of the cellular protein quality control system with a specific role in salt stress response. May facilitate protein homeostasis, together with chemical chaperones that accumulate during the salt stress response. Increased levels of YocM protects against both heat and salt stress. In vitro, displays an unusual aggregase chaperone activity. | 0.700 |
| clpE | clpC | BSU13700 | BSU00860 | ATP-dependent Clp protease (class III stress gene); ATPase essential both for efficient CtsR-dependent gene derepression during heat stress and for rerepression. Together with ClpP, degrades the global regulator CtsR after heat shock. Is also involved in disaggregation of heat-denatured proteins. Has thus a role in overall protein quality control in response to heat stress. | Class III stress response-related ATPase, AAA+ superfamily; Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with MecA to negatively regulate comK; Belongs to the ClpA/ClpB family. ClpC subfamily. | 0.649 |
| clpE | cotP | BSU13700 | BSU05550 | ATP-dependent Clp protease (class III stress gene); ATPase essential both for efficient CtsR-dependent gene derepression during heat stress and for rerepression. Together with ClpP, degrades the global regulator CtsR after heat shock. Is also involved in disaggregation of heat-denatured proteins. Has thus a role in overall protein quality control in response to heat stress. | Spore coat protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor. | 0.661 |
| clpE | dnaK | BSU13700 | BSU25470 | ATP-dependent Clp protease (class III stress gene); ATPase essential both for efficient CtsR-dependent gene derepression during heat stress and for rerepression. Together with ClpP, degrades the global regulator CtsR after heat shock. Is also involved in disaggregation of heat-denatured proteins. Has thus a role in overall protein quality control in response to heat stress. | Molecular chaperone; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.994 |
| clpE | yocM | BSU13700 | BSU19260 | ATP-dependent Clp protease (class III stress gene); ATPase essential both for efficient CtsR-dependent gene derepression during heat stress and for rerepression. Together with ClpP, degrades the global regulator CtsR after heat shock. Is also involved in disaggregation of heat-denatured proteins. Has thus a role in overall protein quality control in response to heat stress. | Putative spore coat protein; Part of the cellular protein quality control system with a specific role in salt stress response. May facilitate protein homeostasis, together with chemical chaperones that accumulate during the salt stress response. Increased levels of YocM protects against both heat and salt stress. In vitro, displays an unusual aggregase chaperone activity. | 0.737 |
| cotP | clpC | BSU05550 | BSU00860 | Spore coat protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor. | Class III stress response-related ATPase, AAA+ superfamily; Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with MecA to negatively regulate comK; Belongs to the ClpA/ClpB family. ClpC subfamily. | 0.661 |
| cotP | clpE | BSU05550 | BSU13700 | Spore coat protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor. | ATP-dependent Clp protease (class III stress gene); ATPase essential both for efficient CtsR-dependent gene derepression during heat stress and for rerepression. Together with ClpP, degrades the global regulator CtsR after heat shock. Is also involved in disaggregation of heat-denatured proteins. Has thus a role in overall protein quality control in response to heat stress. | 0.661 |
| cotP | dnaK | BSU05550 | BSU25470 | Spore coat protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor. | Molecular chaperone; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.627 |
| cotP | yocM | BSU05550 | BSU19260 | Spore coat protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor. | Putative spore coat protein; Part of the cellular protein quality control system with a specific role in salt stress response. May facilitate protein homeostasis, together with chemical chaperones that accumulate during the salt stress response. Increased levels of YocM protects against both heat and salt stress. In vitro, displays an unusual aggregase chaperone activity. | 0.961 |
| dnaK | clpC | BSU25470 | BSU00860 | Molecular chaperone; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Class III stress response-related ATPase, AAA+ superfamily; Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with MecA to negatively regulate comK; Belongs to the ClpA/ClpB family. ClpC subfamily. | 0.996 |
| dnaK | clpE | BSU25470 | BSU13700 | Molecular chaperone; Acts as a chaperone; Belongs to the heat shock protein 70 family. | ATP-dependent Clp protease (class III stress gene); ATPase essential both for efficient CtsR-dependent gene derepression during heat stress and for rerepression. Together with ClpP, degrades the global regulator CtsR after heat shock. Is also involved in disaggregation of heat-denatured proteins. Has thus a role in overall protein quality control in response to heat stress. | 0.994 |
| dnaK | cotP | BSU25470 | BSU05550 | Molecular chaperone; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Spore coat protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor. | 0.627 |
| dnaK | yocM | BSU25470 | BSU19260 | Molecular chaperone; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Putative spore coat protein; Part of the cellular protein quality control system with a specific role in salt stress response. May facilitate protein homeostasis, together with chemical chaperones that accumulate during the salt stress response. Increased levels of YocM protects against both heat and salt stress. In vitro, displays an unusual aggregase chaperone activity. | 0.627 |
| ygzA | yocM | BSU08770 | BSU19260 | Hypothetical protein; Evidence 5: No homology to any previously reported sequences. | Putative spore coat protein; Part of the cellular protein quality control system with a specific role in salt stress response. May facilitate protein homeostasis, together with chemical chaperones that accumulate during the salt stress response. Increased levels of YocM protects against both heat and salt stress. In vitro, displays an unusual aggregase chaperone activity. | 0.843 |
| ygzA | yozO | BSU08770 | BSU19290 | Hypothetical protein; Evidence 5: No homology to any previously reported sequences. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | 0.879 |
| ygzA | yxjH | BSU08770 | BSU38950 | Hypothetical protein; Evidence 5: No homology to any previously reported sequences. | Putative methyl-tetrahydrofolate methyltransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; To B.subtilis YxjG. | 0.817 |
| ygzA | yxjI | BSU08770 | BSU38940 | Hypothetical protein; Evidence 5: No homology to any previously reported sequences. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; Belongs to the LOR family. | 0.741 |
