Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
yoyIConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (76 aa)    
Predicted Functional Partners:
ydiL
Putative membrane protease; May function as endopeptidase which proteolytically removes the C-terminal three residues of farnesylated peptides containing the CAAX motif where C is cysteine, A is an aliphatic amino acid and X is any amino acid; Belongs to the peptidase U48 family.
      
 0.904
yonH
Putative capsid protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps: putative structure.
      
 0.873
yoyH
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function.
  
    0.838
xkdB
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; To B.subtilis YqaL.
      
 0.621
xkdC
Conserved hypothetical protein in PBSX phage element; May function as a transcriptional antiterminator.
      
 0.621
ycgE
Putative transcriptional regulator; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator.
      
 0.519
defB
Formylmethionine deformylase A; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
      
 0.519
pbpF
Penicillin-binding protein 2C required for spore germination; Cell wall formation. May be involved in outgrowth of the germinated spore or it could function in the synthesis of the germ cell wall; In the N-terminal section; belongs to the glycosyltransferase 51 family.
      
 0.451
rseP
Regulator of sigma-W protease RasP; Is responsible for site-2 cleavage of the RsiW anti-sigma factor. This results, after a third proteolytic step catalyzed by the ClpXP protease, in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor. Can also cleave liberated signal peptides of PenP and Mpr, probably within in the cell membrane.
      
 0.450
yopF
Hypothetical protein; Evidence 5: No homology to any previously reported sequences.
  
    0.412
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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