STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
bhlABacteriophage SPbeta holin-like protein; May be involved in the secretion of the autolysin BlyA. (70 aa)    
Predicted Functional Partners:
bhlB
Holin-like bacteriophage SPbeta protein; May be involved in the secretion of the autolysin BlyA; Belongs to the SPP1 holin family.
  
  
 0.992
blyA
Bacteriophage SPbeta N-acetylmuramoyl-L-alanine amidase; Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella and sporulation. Involved in prophage SP-beta-mediated cell lysis.
  
  
 0.969
yomD
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function.
  
  
 0.850
xhlA
Defective prophage PBSX putative enzyme; Associated with cell lysis upon induction of PbsX; To B.licheniformis xpaF1 and xpaL1.
      
 0.846
yomS
Putative phage-related lytic exoenzyme; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme.
   
  
 0.759
xhlB
Bacteriophage PBSX holin; Involved in cell lysis upon induction of PbsX; Belongs to the SPP1 holin family.
     
 0.758
yxzK
Putative integral inner membrane protein involved in export murein hydrolases; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter.
      
 0.757
cidA
Holin regulator of murein hydrolases; Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidA protein. When a cell is stressed by the addition of antibiotics or by other factors in the environment, CidA possibly oligomerizes within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability. These lesions are also hypothesized to [...]
      
 0.750
yomK
Hypothetical protein; Evidence 5: No homology to any previously reported sequences.
  
  
 0.722
xepA
Lytic exoenzyme associated with defective prophage PBSX; Not known; does not seem to be involved in host cell lysis.
      
 0.570
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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