Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| degQ | degR | BSU31720 | BSU21940 | Pleiotropic regulator; Stimulates the phosphotransfer from phospho-DegS to DegU. Affects protease and levansucrose production. | Activation of degradative enzymes (aprE, nprE, sacB) production or activity; Stabilizes the phosphorylated form of DegU, leading to enhanced production of levansucrase, alkaline protease, and neutral protease. | 0.849 |
| degQ | degS | BSU31720 | BSU35500 | Pleiotropic regulator; Stimulates the phosphotransfer from phospho-DegS to DegU. Affects protease and levansucrose production. | Two-component sensor histidine kinase; Member of the two-component regulatory system DegS/DegU, which plays an important role in the transition growth phase. Involved in the control of expression of different cellular functions, including production of degradative enzymes such as the neutral and alkaline proteases, flagellum formation and biofilm formation. Acts as both a protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to DegU, and a protein phosphatase that dephosphorylates phospho-DegU. | 0.920 |
| degQ | sacB | BSU31720 | BSU34450 | Pleiotropic regulator; Stimulates the phosphotransfer from phospho-DegS to DegU. Affects protease and levansucrose production. | Levansucrase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. | 0.682 |
| degQ | sacY | BSU31720 | BSU38420 | Pleiotropic regulator; Stimulates the phosphotransfer from phospho-DegS to DegU. Affects protease and levansucrose production. | Transcriptional antiterminator; In the presence of sucrose, SacY is activated and prevents premature termination of transcription by binding to a RNA- antiterminator (RAT) sequence (partially overlapping with the terminator sequence) located upstream of the sacB gene. Formation of the SacY-RAT complex prevents alternative formation of the terminator, allowing transcription of the sacB gene. In the absence of sucrose, inhibition of SacY activity by SacX leads to termination of transcription; Belongs to the transcriptional antiterminator BglG family. | 0.422 |
| degR | degQ | BSU21940 | BSU31720 | Activation of degradative enzymes (aprE, nprE, sacB) production or activity; Stabilizes the phosphorylated form of DegU, leading to enhanced production of levansucrase, alkaline protease, and neutral protease. | Pleiotropic regulator; Stimulates the phosphotransfer from phospho-DegS to DegU. Affects protease and levansucrose production. | 0.849 |
| degR | degS | BSU21940 | BSU35500 | Activation of degradative enzymes (aprE, nprE, sacB) production or activity; Stabilizes the phosphorylated form of DegU, leading to enhanced production of levansucrase, alkaline protease, and neutral protease. | Two-component sensor histidine kinase; Member of the two-component regulatory system DegS/DegU, which plays an important role in the transition growth phase. Involved in the control of expression of different cellular functions, including production of degradative enzymes such as the neutral and alkaline proteases, flagellum formation and biofilm formation. Acts as both a protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to DegU, and a protein phosphatase that dephosphorylates phospho-DegU. | 0.847 |
| degR | levB | BSU21940 | BSU34460 | Activation of degradative enzymes (aprE, nprE, sacB) production or activity; Stabilizes the phosphorylated form of DegU, leading to enhanced production of levansucrase, alkaline protease, and neutral protease. | Endolevanase; Catalyzes the degradation of levan mainly into levanbiose (difructose). Is not active on sucrose; Belongs to the glycosyl hydrolase 32 family. | 0.483 |
| degR | mecA | BSU21940 | BSU11520 | Activation of degradative enzymes (aprE, nprE, sacB) production or activity; Stabilizes the phosphorylated form of DegU, leading to enhanced production of levansucrase, alkaline protease, and neutral protease. | Adaptor protein controlling oligomerization of the AAA+ protein ClpC; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | 0.576 |
| degR | sacB | BSU21940 | BSU34450 | Activation of degradative enzymes (aprE, nprE, sacB) production or activity; Stabilizes the phosphorylated form of DegU, leading to enhanced production of levansucrase, alkaline protease, and neutral protease. | Levansucrase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. | 0.573 |
| degR | sacY | BSU21940 | BSU38420 | Activation of degradative enzymes (aprE, nprE, sacB) production or activity; Stabilizes the phosphorylated form of DegU, leading to enhanced production of levansucrase, alkaline protease, and neutral protease. | Transcriptional antiterminator; In the presence of sucrose, SacY is activated and prevents premature termination of transcription by binding to a RNA- antiterminator (RAT) sequence (partially overlapping with the terminator sequence) located upstream of the sacB gene. Formation of the SacY-RAT complex prevents alternative formation of the terminator, allowing transcription of the sacB gene. In the absence of sucrose, inhibition of SacY activity by SacX leads to termination of transcription; Belongs to the transcriptional antiterminator BglG family. | 0.473 |
| degR | sigD | BSU21940 | BSU16470 | Activation of degradative enzymes (aprE, nprE, sacB) production or activity; Stabilizes the phosphorylated form of DegU, leading to enhanced production of levansucrase, alkaline protease, and neutral protease. | RNA polymerase sigma-28 factor (sigma-D); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This alternative sigma factor is required for the transcription of the flagellin and motility genes as well as for wild- type chemotaxis. | 0.633 |
| degR | yjcP | BSU21940 | BSU11940 | Activation of degradative enzymes (aprE, nprE, sacB) production or activity; Stabilizes the phosphorylated form of DegU, leading to enhanced production of levansucrase, alkaline protease, and neutral protease. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 15033535. | 0.459 |
| degR | yplP | BSU21940 | BSU21780 | Activation of degradative enzymes (aprE, nprE, sacB) production or activity; Stabilizes the phosphorylated form of DegU, leading to enhanced production of levansucrase, alkaline protease, and neutral protease. | Transcriptional enhancer; May play a role in cold adaptation. | 0.485 |
| degR | ypzA | BSU21940 | BSU21950 | Activation of degradative enzymes (aprE, nprE, sacB) production or activity; Stabilizes the phosphorylated form of DegU, leading to enhanced production of levansucrase, alkaline protease, and neutral protease. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | 0.523 |
| degS | degQ | BSU35500 | BSU31720 | Two-component sensor histidine kinase; Member of the two-component regulatory system DegS/DegU, which plays an important role in the transition growth phase. Involved in the control of expression of different cellular functions, including production of degradative enzymes such as the neutral and alkaline proteases, flagellum formation and biofilm formation. Acts as both a protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to DegU, and a protein phosphatase that dephosphorylates phospho-DegU. | Pleiotropic regulator; Stimulates the phosphotransfer from phospho-DegS to DegU. Affects protease and levansucrose production. | 0.920 |
| degS | degR | BSU35500 | BSU21940 | Two-component sensor histidine kinase; Member of the two-component regulatory system DegS/DegU, which plays an important role in the transition growth phase. Involved in the control of expression of different cellular functions, including production of degradative enzymes such as the neutral and alkaline proteases, flagellum formation and biofilm formation. Acts as both a protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to DegU, and a protein phosphatase that dephosphorylates phospho-DegU. | Activation of degradative enzymes (aprE, nprE, sacB) production or activity; Stabilizes the phosphorylated form of DegU, leading to enhanced production of levansucrase, alkaline protease, and neutral protease. | 0.847 |
| degS | sacB | BSU35500 | BSU34450 | Two-component sensor histidine kinase; Member of the two-component regulatory system DegS/DegU, which plays an important role in the transition growth phase. Involved in the control of expression of different cellular functions, including production of degradative enzymes such as the neutral and alkaline proteases, flagellum formation and biofilm formation. Acts as both a protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to DegU, and a protein phosphatase that dephosphorylates phospho-DegU. | Levansucrase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. | 0.886 |
| degS | sacY | BSU35500 | BSU38420 | Two-component sensor histidine kinase; Member of the two-component regulatory system DegS/DegU, which plays an important role in the transition growth phase. Involved in the control of expression of different cellular functions, including production of degradative enzymes such as the neutral and alkaline proteases, flagellum formation and biofilm formation. Acts as both a protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to DegU, and a protein phosphatase that dephosphorylates phospho-DegU. | Transcriptional antiterminator; In the presence of sucrose, SacY is activated and prevents premature termination of transcription by binding to a RNA- antiterminator (RAT) sequence (partially overlapping with the terminator sequence) located upstream of the sacB gene. Formation of the SacY-RAT complex prevents alternative formation of the terminator, allowing transcription of the sacB gene. In the absence of sucrose, inhibition of SacY activity by SacX leads to termination of transcription; Belongs to the transcriptional antiterminator BglG family. | 0.578 |
| degS | sigD | BSU35500 | BSU16470 | Two-component sensor histidine kinase; Member of the two-component regulatory system DegS/DegU, which plays an important role in the transition growth phase. Involved in the control of expression of different cellular functions, including production of degradative enzymes such as the neutral and alkaline proteases, flagellum formation and biofilm formation. Acts as both a protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to DegU, and a protein phosphatase that dephosphorylates phospho-DegU. | RNA polymerase sigma-28 factor (sigma-D); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This alternative sigma factor is required for the transcription of the flagellin and motility genes as well as for wild- type chemotaxis. | 0.683 |
| levB | degR | BSU34460 | BSU21940 | Endolevanase; Catalyzes the degradation of levan mainly into levanbiose (difructose). Is not active on sucrose; Belongs to the glycosyl hydrolase 32 family. | Activation of degradative enzymes (aprE, nprE, sacB) production or activity; Stabilizes the phosphorylated form of DegU, leading to enhanced production of levansucrase, alkaline protease, and neutral protease. | 0.483 |
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