STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gndA6-phosphogluconate dehydrogenase, NADP(+)-dependent, decarboxylating; Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. Is the predominant 6-P- gluconate dehydrogenase isoenzyme in B.subtilis during growth on glucose and gluconate (469 aa)    
Predicted Functional Partners:
zwf
Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
 
 
 0.991
pgl
6-phosphogluconolactonase; Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate
 
  
 0.952
gntK
Gluconokinase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme
 
  
 0.948
ywjH
Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. Does not show fructose-6-P aldolase activity
  
 
 0.945
rpe
Ribulose-phosphate 3-epimerase; Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate
  
 0.933
ywlF
Putative sugar phosphate isomerase YwlF; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme
    
  0.907
hxlA
3-hexulose-6-phosphate synthase; Catalyzes the condensation of ribulose 5-phosphate with formaldehyde to form 3-hexulose 6-phosphate. Together with HxlB, may act as a formaldehyde detoxification system; Belongs to the HPS/KGPDC family. HPS subfamily
    
  0.904
tkt
Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
  
 
 0.891
yqeC
Putative 6-phosphogluconate dehydrogenase YqeC; May act as NAD-dependent 6-P-gluconate dehydrogenase
  
 
0.855
kduD
2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase; Catalyzes the reduction of 2,5-diketo-3-deoxygluconate (DKII or 4,6-dihydroxy-2,5-dioxohexanoate) into 2-keto-3- deoxygluconate (KDG or 2-dehydro-3-deoxygluconate) with a concomitant oxidation of NADH; Belongs to the short-chain dehydrogenases/reductases (SDR) family
  
 
  0.813
Your Current Organism:
Bacillus subtilis
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis, Bacillus subtilis 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
Server load: low (10%) [HD]