node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
gndA | gntK | BSU23860 | BSU40060 | NADP+-dependent 6-P-gluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. Is the predominant 6-P-gluconate dehydrogenase isoenzyme in B.subtilis during growth on glucose and gluconate. | Gluconate kinase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. | 0.917 |
gndA | gntZ | BSU23860 | BSU40080 | NADP+-dependent 6-P-gluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. Is the predominant 6-P-gluconate dehydrogenase isoenzyme in B.subtilis during growth on glucose and gluconate. | NAD+-6-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NAD to NADH. Does not contribute to oxidative pentose phosphate (PP) pathway fluxes during growth on glucose. The functional role of GntZ remains obscure. | 0.904 |
gndA | hxlA | BSU23860 | BSU03460 | NADP+-dependent 6-P-gluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. Is the predominant 6-P-gluconate dehydrogenase isoenzyme in B.subtilis during growth on glucose and gluconate. | 3-hexulose-6-phosphate synthase (HPS); Catalyzes the condensation of ribulose 5-phosphate with formaldehyde to form 3-hexulose 6-phosphate. Together with HxlB, may act as a formaldehyde detoxification system; Belongs to the HPS/KGPDC family. HPS subfamily. | 0.901 |
gndA | pgl | BSU23860 | BSU13010 | NADP+-dependent 6-P-gluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. Is the predominant 6-P-gluconate dehydrogenase isoenzyme in B.subtilis during growth on glucose and gluconate. | 6-phosphogluconolactonase; Catalyzes the hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate. | 0.956 |
gndA | rpe | BSU23860 | BSU15790 | NADP+-dependent 6-P-gluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. Is the predominant 6-P-gluconate dehydrogenase isoenzyme in B.subtilis during growth on glucose and gluconate. | Ribulose-5-phosphate 3-epimerase; Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate; Belongs to the ribulose-phosphate 3-epimerase family. | 0.944 |
gndA | tkt | BSU23860 | BSU17890 | NADP+-dependent 6-P-gluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. Is the predominant 6-P-gluconate dehydrogenase isoenzyme in B.subtilis during growth on glucose and gluconate. | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. | 0.890 |
gndA | yqeC | BSU23860 | BSU25730 | NADP+-dependent 6-P-gluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. Is the predominant 6-P-gluconate dehydrogenase isoenzyme in B.subtilis during growth on glucose and gluconate. | Putative hydroxyacid dehydrogenase; May act as NAD-dependent 6-P-gluconate dehydrogenase. | 0.930 |
gndA | ywjH | BSU23860 | BSU37110 | NADP+-dependent 6-P-gluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. Is the predominant 6-P-gluconate dehydrogenase isoenzyme in B.subtilis during growth on glucose and gluconate. | Putative transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. Does not show fructose-6-P aldolase activity. | 0.866 |
gndA | ywlF | BSU23860 | BSU36920 | NADP+-dependent 6-P-gluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. Is the predominant 6-P-gluconate dehydrogenase isoenzyme in B.subtilis during growth on glucose and gluconate. | Ribose 5-phosphate epimerase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. | 0.938 |
gndA | zwf | BSU23860 | BSU23850 | NADP+-dependent 6-P-gluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. Is the predominant 6-P-gluconate dehydrogenase isoenzyme in B.subtilis during growth on glucose and gluconate. | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | 0.996 |
gntK | gndA | BSU40060 | BSU23860 | Gluconate kinase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. | NADP+-dependent 6-P-gluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. Is the predominant 6-P-gluconate dehydrogenase isoenzyme in B.subtilis during growth on glucose and gluconate. | 0.917 |
gntK | gntZ | BSU40060 | BSU40080 | Gluconate kinase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. | NAD+-6-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NAD to NADH. Does not contribute to oxidative pentose phosphate (PP) pathway fluxes during growth on glucose. The functional role of GntZ remains obscure. | 0.997 |
gntK | pgl | BSU40060 | BSU13010 | Gluconate kinase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. | 6-phosphogluconolactonase; Catalyzes the hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate. | 0.938 |
gntK | tkt | BSU40060 | BSU17890 | Gluconate kinase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. | 0.445 |
gntK | yqeC | BSU40060 | BSU25730 | Gluconate kinase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. | Putative hydroxyacid dehydrogenase; May act as NAD-dependent 6-P-gluconate dehydrogenase. | 0.937 |
gntK | ywjH | BSU40060 | BSU37110 | Gluconate kinase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. | Putative transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. Does not show fructose-6-P aldolase activity. | 0.502 |
gntK | zwf | BSU40060 | BSU23850 | Gluconate kinase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | 0.737 |
gntZ | gndA | BSU40080 | BSU23860 | NAD+-6-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NAD to NADH. Does not contribute to oxidative pentose phosphate (PP) pathway fluxes during growth on glucose. The functional role of GntZ remains obscure. | NADP+-dependent 6-P-gluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. Is the predominant 6-P-gluconate dehydrogenase isoenzyme in B.subtilis during growth on glucose and gluconate. | 0.904 |
gntZ | gntK | BSU40080 | BSU40060 | NAD+-6-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NAD to NADH. Does not contribute to oxidative pentose phosphate (PP) pathway fluxes during growth on glucose. The functional role of GntZ remains obscure. | Gluconate kinase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. | 0.997 |
gntZ | hxlA | BSU40080 | BSU03460 | NAD+-6-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NAD to NADH. Does not contribute to oxidative pentose phosphate (PP) pathway fluxes during growth on glucose. The functional role of GntZ remains obscure. | 3-hexulose-6-phosphate synthase (HPS); Catalyzes the condensation of ribulose 5-phosphate with formaldehyde to form 3-hexulose 6-phosphate. Together with HxlB, may act as a formaldehyde detoxification system; Belongs to the HPS/KGPDC family. HPS subfamily. | 0.901 |