STRING protein interaction network
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
protein homology
Your Input:
Gene Fusion
sipWType i signal peptidase; Required for the cleavage of the signal sequence of TasA and TapA, which are involved in biofilm formation (190 aa)    
Predicted Functional Partners:
Lipoprotein for biofilm formation; Required for biofilm formation Required for the proper anchoring and polymerization of TasA amyloid fibers at the cell surface . Is also a minor component of TasA fibers
Xre family transcriptional regulator, master regulator for biofilm formation; Negative as well as positive regulator of alternate developmental processes that are induced at the end of vegetative growth in response to nutrient depletion. Binds to the alkaline protease (aprE) gene at two sites. Also acts as a repressor of the key sporulation gene spo0A. Negatively regulates transcription of the eps operon, which is responsible for the biosynthesis of an exopolysaccharide involved in biofilm formation; therefore it could govern the transition between a state in which bacteria swim or swa [...]
Uncharacterized protein YveK; Evidence 2b: Function of strongly homologous gene; Product type r : regulator
Hth-type transcriptional regulator, biofilm formation regulator; Represses sigma(D)-dependent flagellar genes and activate the eps and yqxM operons. Repressor activity is regulated by SlrA. Controls the initiation of biofilm formation
Acts as an antagonist to SinR. SinI prevents SinR from binding to its target sequence on the gene for AprE
Spore coat-associated protein n; TasA is the major protein component of the biofilm extracellular matrix . It forms amyloid fibers that bind cells together in the biofilm . Exhibits an antibacterial activity against a variety of Gram-positive and Gram-negative bacteria . In laboratory strains, is also involved in proper spore coat assembly
Biofilm hydrophobic layer component; Involved in biofilm formation Self-polymerizes and forms a layer on the surface of biofilms that confers hydrophobicity to the biofilm The layer is stable and capable of resistance to high mechanical force compression . Required for complex colony architecture . May function synergistically with exopolysaccharides and TasA amyloid fibers to facilitate the assembly of the biofilm matrix
Two-component system, response regulator, stage 0 sporulation protein a; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with Spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. Repressor of abrB, activator of the spoIIa operon. Binds the DNA sequence 5'-TGNCGAA-3' (0A box)
Abrb family transcriptional regulator, transcriptional pleiotropic regulator of transition state genes; Ambiactive repressor and activator of the transcription of genes expressed during the transition state between vegetative growth and the onset of stationary phase and sporulation. It controls the expression of genes spovG and tycA. AbrB binds to the tycA promoter region at two A- and T-rich sites, it may be the sole repressor of tycA transcription
Putative pyruvyl transferase; May be involved in the production of the exopolysaccharide (EPS) component of the extracellular matrix during biofilm formation. EPS is responsible for the adhesion of chains of cells into bundles
Your Current Organism:
Bacillus subtilis
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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