Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
yqfLPositive regulator of gluconeogenesis; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation. (270 aa)    
Predicted Functional Partners:
ccpN
Negative regulator of gluconeogenesis; Transcription repressor that binds to the promoter of gapB and pckA genes, preventing their expression. Acts as a regulator for catabolite repression of gluconeogenic genes.
 
  
 0.994
glyS
glycyl-tRNA synthetase (beta subunit); Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type e: enzyme.
 
    0.847
yqxD
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 9387153; Belongs to the UPF0178 family.
  
  
 0.846
glyQ
glycyl-tRNA synthetase (alpha subunit); Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type e: enzyme.
 
  
 0.725
dnaG
DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
  
  
 0.693
yabM
Putative exporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter.
  
   
 0.687
sigA
RNA polymerase major sigma-43 factor (sigma-A); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth; Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
 
  
 0.652
pps
Putative PEP-dependent enzyme; Might catalyze the phosphorylation of pyruvate to phosphoenolpyruvate.
  
  
 0.556
yqfO
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function.
  
    0.556
yvkC
Putative phosphotransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the PEP-utilizing enzyme family.
  
  
 0.556
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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