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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
Score
gprSpore endopeptidase; Initiates the degradation of small, acid-soluble proteins during spore germination. (368 aa)    
Predicted Functional Partners:
spoVAD
Stage V sporulation protein AD; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process.
  
  
 0.976
spoVAC
Stage V sporulation protein AC; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process.
  
  
 0.970
spoIIP
Spore autolysin (stage II sporulation); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process.
 
  
 0.967
yyaC
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function.
  
  
 0.935
spoVAEB
Spore germinant protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process.
  
  
 0.895
gerAA
Component of the GerA germination receptor; Forms a complex at the inner spore membrane which acts as a receptor for L-alanine, thus is involved in the stimulation of germination in response to alanine. Can stimulate germination in the absence of GerD and GerK gene products (fructose and glucose receptors, respectively), but the response is improved in their presence.
  
  
 0.885
spoIVA
Morphogenetic stage IV sporulation protein; ATPase. Has a role at an early stage in the morphogenesis of the spore coat outer layers. Its ATP hydrolysis is required for proper assembly of the spore coat. Forms a basement layer around the outside surface of the forespore and self-assembles irreversibly into higher order structures by binding and hydrolyzing ATP thus creating a durable and stable platform upon which thereafter morphogenesis of the coat can take place. Required for proper localization of spore coat protein CotE and sporulation-specific proteins including SpoVM.
  
  
 0.859
ytfJ
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function.
  
    0.819
spoIVB
Regulatory membrane-associated serine protease; Plays a central role in the sigma-K checkpoint which coordinates gene expression during the later stages of spore formation. The protease is activated by trans cleavage of the zymogen precursor producing SpoIVB-45 kDa. This undergoes further trimming by cis cleavage to form SpoIVB-43 kDa and SpoIVB-42 kDa. The protease then cleaves the C-terminus of the SpoIVFA metalloprotease activating the latter.
  
    0.813
tepA
Protein export-enhancing factor; Required for efficient translocation of pre-proteins across the membrane; Belongs to the peptidase S14 family. TepA subfamily.
  
  
 0.812
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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