node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cmk | comEB | BSU22890 | BSU25580 | Cytidylate kinase; Evidence 1a: Function experimentally demonstrated in the studied strain; enzyme. | Putative enzyme associated to DNA transport (competence); Dispensable for transformability; Belongs to the cytidine and deoxycytidylate deaminase family. | 0.903 |
cmk | dck | BSU22890 | BSU00140 | Cytidylate kinase; Evidence 1a: Function experimentally demonstrated in the studied strain; enzyme. | Deoxyadenosine/deoxycytidine kinase; Plays an essential role in generating the deoxyribonucleotide precursors dATP AND dCTP for DNA metabolism. The phosphate acceptor specificity is strict toward deoxyadenosine (dAdo) and deoxycytidine (dCyd). The specificity toward the sugar moiety of the nucleoside is less strict. Both 2-deoxyribose, ribose, and arabinose nucleosides are phosphorylated, although the 2-deoxyribonucleosides are preferred. The phosphate donor specificity is dependent on the deoxyribonucleoside substrate, but GTP is efficient with both deoxycytidine and deoxyadenosine. O [...] | 0.914 |
cmk | tdk | BSU22890 | BSU37060 | Cytidylate kinase; Evidence 1a: Function experimentally demonstrated in the studied strain; enzyme. | Thymidine kinase; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type e: enzyme. | 0.698 |
cmk | yfkN | BSU22890 | BSU07840 | Cytidylate kinase; Evidence 1a: Function experimentally demonstrated in the studied strain; enzyme. | Exported 2',3'-cyclic-nucleotide 2'-phosphodiesterase, 2' (or 3') nucleotidase and 5' nucleotidase; Catalyzes the release of inorganic phosphate from 2',3'- cyclic nucleotides through consecutive 2',3'-phosphodiesterase and 3'- (or 2') nucleotidase activities. Also possesses a 5'-nucleotidase activity. Does not catalyze the release of inorganic phosphate from 3',5'-cyclic nucleotides. Probably plays a role in the cellular reprocessing of nucleotides present in the medium, under conditions of phosphate shortage. | 0.900 |
cmk | yncF | BSU22890 | BSU17660 | Cytidylate kinase; Evidence 1a: Function experimentally demonstrated in the studied strain; enzyme. | Deoxyuridine 5'-triphosphate pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.443 |
cmk | yosS | BSU22890 | BSU20020 | Cytidylate kinase; Evidence 1a: Function experimentally demonstrated in the studied strain; enzyme. | SPbeta phage deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.441 |
comEB | cmk | BSU25580 | BSU22890 | Putative enzyme associated to DNA transport (competence); Dispensable for transformability; Belongs to the cytidine and deoxycytidylate deaminase family. | Cytidylate kinase; Evidence 1a: Function experimentally demonstrated in the studied strain; enzyme. | 0.903 |
comEB | comEC | BSU25580 | BSU25570 | Putative enzyme associated to DNA transport (competence); Dispensable for transformability; Belongs to the cytidine and deoxycytidylate deaminase family. | DNA channel for uptake in competent cells; The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding; To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI. | 0.917 |
comEB | dck | BSU25580 | BSU00140 | Putative enzyme associated to DNA transport (competence); Dispensable for transformability; Belongs to the cytidine and deoxycytidylate deaminase family. | Deoxyadenosine/deoxycytidine kinase; Plays an essential role in generating the deoxyribonucleotide precursors dATP AND dCTP for DNA metabolism. The phosphate acceptor specificity is strict toward deoxyadenosine (dAdo) and deoxycytidine (dCyd). The specificity toward the sugar moiety of the nucleoside is less strict. Both 2-deoxyribose, ribose, and arabinose nucleosides are phosphorylated, although the 2-deoxyribonucleosides are preferred. The phosphate donor specificity is dependent on the deoxyribonucleoside substrate, but GTP is efficient with both deoxycytidine and deoxyadenosine. O [...] | 0.921 |
comEB | tdk | BSU25580 | BSU37060 | Putative enzyme associated to DNA transport (competence); Dispensable for transformability; Belongs to the cytidine and deoxycytidylate deaminase family. | Thymidine kinase; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type e: enzyme. | 0.970 |
comEB | thyA | BSU25580 | BSU17680 | Putative enzyme associated to DNA transport (competence); Dispensable for transformability; Belongs to the cytidine and deoxycytidylate deaminase family. | Hypothetical protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.929 |
comEB | thyB | BSU25580 | BSU21820 | Putative enzyme associated to DNA transport (competence); Dispensable for transformability; Belongs to the cytidine and deoxycytidylate deaminase family. | Thymidylate synthase B; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.929 |
comEB | tmk | BSU25580 | BSU00280 | Putative enzyme associated to DNA transport (competence); Dispensable for transformability; Belongs to the cytidine and deoxycytidylate deaminase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.922 |
comEB | yfkN | BSU25580 | BSU07840 | Putative enzyme associated to DNA transport (competence); Dispensable for transformability; Belongs to the cytidine and deoxycytidylate deaminase family. | Exported 2',3'-cyclic-nucleotide 2'-phosphodiesterase, 2' (or 3') nucleotidase and 5' nucleotidase; Catalyzes the release of inorganic phosphate from 2',3'- cyclic nucleotides through consecutive 2',3'-phosphodiesterase and 3'- (or 2') nucleotidase activities. Also possesses a 5'-nucleotidase activity. Does not catalyze the release of inorganic phosphate from 3',5'-cyclic nucleotides. Probably plays a role in the cellular reprocessing of nucleotides present in the medium, under conditions of phosphate shortage. | 0.904 |
comEB | yncF | BSU25580 | BSU17660 | Putative enzyme associated to DNA transport (competence); Dispensable for transformability; Belongs to the cytidine and deoxycytidylate deaminase family. | Deoxyuridine 5'-triphosphate pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.935 |
comEB | yosS | BSU25580 | BSU20020 | Putative enzyme associated to DNA transport (competence); Dispensable for transformability; Belongs to the cytidine and deoxycytidylate deaminase family. | SPbeta phage deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.935 |
comEC | comEB | BSU25570 | BSU25580 | DNA channel for uptake in competent cells; The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding; To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI. | Putative enzyme associated to DNA transport (competence); Dispensable for transformability; Belongs to the cytidine and deoxycytidylate deaminase family. | 0.917 |
dck | cmk | BSU00140 | BSU22890 | Deoxyadenosine/deoxycytidine kinase; Plays an essential role in generating the deoxyribonucleotide precursors dATP AND dCTP for DNA metabolism. The phosphate acceptor specificity is strict toward deoxyadenosine (dAdo) and deoxycytidine (dCyd). The specificity toward the sugar moiety of the nucleoside is less strict. Both 2-deoxyribose, ribose, and arabinose nucleosides are phosphorylated, although the 2-deoxyribonucleosides are preferred. The phosphate donor specificity is dependent on the deoxyribonucleoside substrate, but GTP is efficient with both deoxycytidine and deoxyadenosine. O [...] | Cytidylate kinase; Evidence 1a: Function experimentally demonstrated in the studied strain; enzyme. | 0.914 |
dck | comEB | BSU00140 | BSU25580 | Deoxyadenosine/deoxycytidine kinase; Plays an essential role in generating the deoxyribonucleotide precursors dATP AND dCTP for DNA metabolism. The phosphate acceptor specificity is strict toward deoxyadenosine (dAdo) and deoxycytidine (dCyd). The specificity toward the sugar moiety of the nucleoside is less strict. Both 2-deoxyribose, ribose, and arabinose nucleosides are phosphorylated, although the 2-deoxyribonucleosides are preferred. The phosphate donor specificity is dependent on the deoxyribonucleoside substrate, but GTP is efficient with both deoxycytidine and deoxyadenosine. O [...] | Putative enzyme associated to DNA transport (competence); Dispensable for transformability; Belongs to the cytidine and deoxycytidylate deaminase family. | 0.921 |
dck | tdk | BSU00140 | BSU37060 | Deoxyadenosine/deoxycytidine kinase; Plays an essential role in generating the deoxyribonucleotide precursors dATP AND dCTP for DNA metabolism. The phosphate acceptor specificity is strict toward deoxyadenosine (dAdo) and deoxycytidine (dCyd). The specificity toward the sugar moiety of the nucleoside is less strict. Both 2-deoxyribose, ribose, and arabinose nucleosides are phosphorylated, although the 2-deoxyribonucleosides are preferred. The phosphate donor specificity is dependent on the deoxyribonucleoside substrate, but GTP is efficient with both deoxycytidine and deoxyadenosine. O [...] | Thymidine kinase; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type e: enzyme. | 0.609 |