comER protein (Bacillus subtilis 168) - STRING interaction network

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comER

Putative pyrroline-5'-carboxylate reductase; Dispensable for transformability. Not known if it can act as a pyrroline-5-carboxylate reductase. (273 aa)

Predicted Functional Partners:

comEB

0.896

comEA

0.877

comEC

0.844

proJ

0.821

proA

0.818

proB

0.677

proI

0.528

ywdK

0.519

gltA

0.503

rocD

0.502

Your Current Organism:

Bacillus subtilis 168

NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
comEA	comEB	BSU25590	BSU25580	Membrane bound high-affinity DNA-binding receptor; Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect.	Putative enzyme associated to DNA transport (competence); Dispensable for transformability; Belongs to the cytidine and deoxycytidylate deaminase family.	0.988
comEA	comEC	BSU25590	BSU25570	Membrane bound high-affinity DNA-binding receptor; Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect.	DNA channel for uptake in competent cells; The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding; To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI.	0.999
comEA	comER	BSU25590	BSU25600	Membrane bound high-affinity DNA-binding receptor; Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect.	Putative pyrroline-5'-carboxylate reductase; Dispensable for transformability. Not known if it can act as a pyrroline-5-carboxylate reductase.	0.877
comEB	comEA	BSU25580	BSU25590	Putative enzyme associated to DNA transport (competence); Dispensable for transformability; Belongs to the cytidine and deoxycytidylate deaminase family.	Membrane bound high-affinity DNA-binding receptor; Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect.	0.988
comEB	comEC	BSU25580	BSU25570	Putative enzyme associated to DNA transport (competence); Dispensable for transformability; Belongs to the cytidine and deoxycytidylate deaminase family.	DNA channel for uptake in competent cells; The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding; To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI.	0.994
comEB	comER	BSU25580	BSU25600	Putative enzyme associated to DNA transport (competence); Dispensable for transformability; Belongs to the cytidine and deoxycytidylate deaminase family.	Putative pyrroline-5'-carboxylate reductase; Dispensable for transformability. Not known if it can act as a pyrroline-5-carboxylate reductase.	0.896
comEC	comEA	BSU25570	BSU25590	DNA channel for uptake in competent cells; The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding; To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI.	Membrane bound high-affinity DNA-binding receptor; Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect.	0.999
comEC	comEB	BSU25570	BSU25580	DNA channel for uptake in competent cells; The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding; To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI.	Putative enzyme associated to DNA transport (competence); Dispensable for transformability; Belongs to the cytidine and deoxycytidylate deaminase family.	0.994
comEC	comER	BSU25570	BSU25600	DNA channel for uptake in competent cells; The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding; To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI.	Putative pyrroline-5'-carboxylate reductase; Dispensable for transformability. Not known if it can act as a pyrroline-5-carboxylate reductase.	0.844
comEC	proA	BSU25570	BSU13130	DNA channel for uptake in competent cells; The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding; To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI.	Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.	0.610
comEC	proB	BSU25570	BSU13120	DNA channel for uptake in competent cells; The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding; To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI.	Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.	0.428
comEC	proJ	BSU25570	BSU18470	DNA channel for uptake in competent cells; The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding; To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI.	Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.	0.428
comER	comEA	BSU25600	BSU25590	Putative pyrroline-5'-carboxylate reductase; Dispensable for transformability. Not known if it can act as a pyrroline-5-carboxylate reductase.	Membrane bound high-affinity DNA-binding receptor; Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect.	0.877
comER	comEB	BSU25600	BSU25580	Putative pyrroline-5'-carboxylate reductase; Dispensable for transformability. Not known if it can act as a pyrroline-5-carboxylate reductase.	Putative enzyme associated to DNA transport (competence); Dispensable for transformability; Belongs to the cytidine and deoxycytidylate deaminase family.	0.896
comER	comEC	BSU25600	BSU25570	Putative pyrroline-5'-carboxylate reductase; Dispensable for transformability. Not known if it can act as a pyrroline-5-carboxylate reductase.	DNA channel for uptake in competent cells; The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding; To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI.	0.844
comER	gltA	BSU25600	BSU18450	Putative pyrroline-5'-carboxylate reductase; Dispensable for transformability. Not known if it can act as a pyrroline-5-carboxylate reductase.	Glutamate synthase (large subunit); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the glutamate synthase family.	0.503
comER	proA	BSU25600	BSU13130	Putative pyrroline-5'-carboxylate reductase; Dispensable for transformability. Not known if it can act as a pyrroline-5-carboxylate reductase.	Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.	0.818
comER	proB	BSU25600	BSU13120	Putative pyrroline-5'-carboxylate reductase; Dispensable for transformability. Not known if it can act as a pyrroline-5-carboxylate reductase.	Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.	0.677
comER	proI	BSU25600	BSU23800	Putative pyrroline-5'-carboxylate reductase; Dispensable for transformability. Not known if it can act as a pyrroline-5-carboxylate reductase.	Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.	0.528
comER	proJ	BSU25600	BSU18470	Putative pyrroline-5'-carboxylate reductase; Dispensable for transformability. Not known if it can act as a pyrroline-5-carboxylate reductase.	Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.	0.821

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