STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
arsRTranscriptional regulator (ArsR family); Transcriptional repressor for the ars operon. (105 aa)    
Predicted Functional Partners:
arsC
Thioredoxin-coupled arsenate reductase; Catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)]. In vitro, can dephosphorylate para- nitrophenyl phosphate (pNPP). Belongs to the low molecular weight phosphotyrosine protein phosphatase family. Thioredoxin-coupled ArsC subfamily.
 
  
 0.994
czrA
Transcriptional regulator (multiple metal-sensing ArsR-SmtB transcriptional repressors family); Metal-responsive transcriptional regulator that represses transcription of cadA and the czcD-trkA operon by binding specifically to their promoter. Binding of zinc causes the repressor to dissociate from the DNA.
 
  
 0.992
arsB
Arsenite efflux transporter; Seems to confer resistance to arsenite by allowing cells to extrude this compound. Could be part of an arsenite extrusion pump.
 
  
 0.990
yqcK
Putative thiol lyase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; To M.tuberculosis Rv2641.
  
  
 0.972
csoR
Repressor of copper utilisation proteins; Copper-sensitive repressor that has a key role in copper homeostasis. Negatively regulates expression of the copZA operon and of ycnJ. In the absence of copper ions, binds with high affinity to the copZA promoter and represses the transcription. In the presence of copper ions, CsoR binds Cu(1+), which significantly decreases its DNA binding affinity and leads to the transcription of the genes.
  
  
 0.923
padR
Transcriptional regulator of PadC; Negative transcriptional regulator of padC phenolic acid decarboxylase.
   
  
 0.854
cueR
Copper efflux transcriptional regulator; Transcriptional activator of the copZA operon.
   
  
 0.849
xre
Phage PBSX transcriptional regulator; Repressor of PBSX. Binds to four sites close to its own gene. Necessary for the maintenance of the lysogenic state.
   
  
 0.692
ywrK
Putative Na+/H+ antiporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter.
 
  
 0.647
yrdQ
Putative transcriptional regulator (LysR family); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator; Belongs to the LysR transcriptional regulatory family.
   
  
 0.619
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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