| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| blt | bltD | BSU26590 | BSU26600 | Efflux transporter; Energy-dependent efflux pump responsible for decreased drug accumulation in multi-drug-resistant cells. Probably uses a transmembrane proton gradient as the energy source. Causes the efflux of a variety of toxic substances, including such structurally diverse compounds as ethidium bromide, rhodamine and acridine dyes, tetraphenylphosphonium, puromycin, chloramphenicol, doxorubicin, and fluoroquinolone antibiotics; Belongs to the major facilitator superfamily. TCR/Tet family. | Spermine/spermidine acetyltransferase; Acetylates both spermidine and spermine at primary propyl amine moieties, with spermine being the preferred substrate. | 0.981 |
| blt | bltR | BSU26590 | BSU26580 | Efflux transporter; Energy-dependent efflux pump responsible for decreased drug accumulation in multi-drug-resistant cells. Probably uses a transmembrane proton gradient as the energy source. Causes the efflux of a variety of toxic substances, including such structurally diverse compounds as ethidium bromide, rhodamine and acridine dyes, tetraphenylphosphonium, puromycin, chloramphenicol, doxorubicin, and fluoroquinolone antibiotics; Belongs to the major facilitator superfamily. TCR/Tet family. | Transcriptional regulator; Activates transcription of the blt gene in response to structurally dissimilar drugs. | 0.575 |
| bltD | blt | BSU26600 | BSU26590 | Spermine/spermidine acetyltransferase; Acetylates both spermidine and spermine at primary propyl amine moieties, with spermine being the preferred substrate. | Efflux transporter; Energy-dependent efflux pump responsible for decreased drug accumulation in multi-drug-resistant cells. Probably uses a transmembrane proton gradient as the energy source. Causes the efflux of a variety of toxic substances, including such structurally diverse compounds as ethidium bromide, rhodamine and acridine dyes, tetraphenylphosphonium, puromycin, chloramphenicol, doxorubicin, and fluoroquinolone antibiotics; Belongs to the major facilitator superfamily. TCR/Tet family. | 0.981 |
| bltD | bltR | BSU26600 | BSU26580 | Spermine/spermidine acetyltransferase; Acetylates both spermidine and spermine at primary propyl amine moieties, with spermine being the preferred substrate. | Transcriptional regulator; Activates transcription of the blt gene in response to structurally dissimilar drugs. | 0.698 |
| bltD | feuB | BSU26600 | BSU01620 | Spermine/spermidine acetyltransferase; Acetylates both spermidine and spermine at primary propyl amine moieties, with spermine being the preferred substrate. | Iron-uptake protein; Involved in the uptake of iron. Probably responsible for the translocation of the substrate across the membrane. | 0.568 |
| bltD | feuC | BSU26600 | BSU01610 | Spermine/spermidine acetyltransferase; Acetylates both spermidine and spermine at primary propyl amine moieties, with spermine being the preferred substrate. | Iron-uptake protein; Involved in the uptake of iron. Probably responsible for the translocation of the substrate across the membrane. | 0.714 |
| bltD | paiA | BSU26600 | BSU32150 | Spermine/spermidine acetyltransferase; Acetylates both spermidine and spermine at primary propyl amine moieties, with spermine being the preferred substrate. | Polyamine N-acetyltransferase; Involved in the protection against polyamine toxicity by regulating their concentration. Also could be involved in the negative control of sporulation as well as production of degradative enzymes such as alpha-amylase, levansucrase and alkaline phosphatase. Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and releases both CoA and the acetylated product. It possesses N1-acetyltransferase activity toward polyamine substrates including spermidine, spermine, aminopropylcadaverine, norspermidine, homospermidine [...] | 0.913 |
| bltD | prmC | BSU26600 | BSU37000 | Spermine/spermidine acetyltransferase; Acetylates both spermidine and spermine at primary propyl amine moieties, with spermine being the preferred substrate. | Glutamine methylase of release factor 1 (and perhaps others) at a GGQ site; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. | 0.647 |
| bltD | speB | BSU26600 | BSU37490 | Spermine/spermidine acetyltransferase; Acetylates both spermidine and spermine at primary propyl amine moieties, with spermine being the preferred substrate. | Agmatinase; Catalyzes the formation of putrescine from agmatine; Belongs to the arginase family. Agmatinase subfamily. | 0.900 |
| bltD | speE | BSU26600 | BSU37500 | Spermine/spermidine acetyltransferase; Acetylates both spermidine and spermine at primary propyl amine moieties, with spermine being the preferred substrate. | Spermidine synthase; Involved in the cell growth and proliferation. Catalyzes the irreversible transfer of a propylamine group from the amino donor S- adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4- diaminobutane) to yield spermidine (Probable). Belongs to the spermidine/spermine synthase family. | 0.900 |
| bltD | ydjO | BSU26600 | BSU06270 | Spermine/spermidine acetyltransferase; Acetylates both spermidine and spermine at primary propyl amine moieties, with spermine being the preferred substrate. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | 0.807 |
| bltD | yraL | BSU26600 | BSU26900 | Spermine/spermidine acetyltransferase; Acetylates both spermidine and spermine at primary propyl amine moieties, with spermine being the preferred substrate. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | 0.580 |
| bltR | blt | BSU26580 | BSU26590 | Transcriptional regulator; Activates transcription of the blt gene in response to structurally dissimilar drugs. | Efflux transporter; Energy-dependent efflux pump responsible for decreased drug accumulation in multi-drug-resistant cells. Probably uses a transmembrane proton gradient as the energy source. Causes the efflux of a variety of toxic substances, including such structurally diverse compounds as ethidium bromide, rhodamine and acridine dyes, tetraphenylphosphonium, puromycin, chloramphenicol, doxorubicin, and fluoroquinolone antibiotics; Belongs to the major facilitator superfamily. TCR/Tet family. | 0.575 |
| bltR | bltD | BSU26580 | BSU26600 | Transcriptional regulator; Activates transcription of the blt gene in response to structurally dissimilar drugs. | Spermine/spermidine acetyltransferase; Acetylates both spermidine and spermine at primary propyl amine moieties, with spermine being the preferred substrate. | 0.698 |
| feuB | bltD | BSU01620 | BSU26600 | Iron-uptake protein; Involved in the uptake of iron. Probably responsible for the translocation of the substrate across the membrane. | Spermine/spermidine acetyltransferase; Acetylates both spermidine and spermine at primary propyl amine moieties, with spermine being the preferred substrate. | 0.568 |
| feuB | feuC | BSU01620 | BSU01610 | Iron-uptake protein; Involved in the uptake of iron. Probably responsible for the translocation of the substrate across the membrane. | Iron-uptake protein; Involved in the uptake of iron. Probably responsible for the translocation of the substrate across the membrane. | 0.976 |
| feuC | bltD | BSU01610 | BSU26600 | Iron-uptake protein; Involved in the uptake of iron. Probably responsible for the translocation of the substrate across the membrane. | Spermine/spermidine acetyltransferase; Acetylates both spermidine and spermine at primary propyl amine moieties, with spermine being the preferred substrate. | 0.714 |
| feuC | feuB | BSU01610 | BSU01620 | Iron-uptake protein; Involved in the uptake of iron. Probably responsible for the translocation of the substrate across the membrane. | Iron-uptake protein; Involved in the uptake of iron. Probably responsible for the translocation of the substrate across the membrane. | 0.976 |
| paiA | bltD | BSU32150 | BSU26600 | Polyamine N-acetyltransferase; Involved in the protection against polyamine toxicity by regulating their concentration. Also could be involved in the negative control of sporulation as well as production of degradative enzymes such as alpha-amylase, levansucrase and alkaline phosphatase. Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and releases both CoA and the acetylated product. It possesses N1-acetyltransferase activity toward polyamine substrates including spermidine, spermine, aminopropylcadaverine, norspermidine, homospermidine [...] | Spermine/spermidine acetyltransferase; Acetylates both spermidine and spermine at primary propyl amine moieties, with spermine being the preferred substrate. | 0.913 |
| prmC | bltD | BSU37000 | BSU26600 | Glutamine methylase of release factor 1 (and perhaps others) at a GGQ site; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. | Spermine/spermidine acetyltransferase; Acetylates both spermidine and spermine at primary propyl amine moieties, with spermine being the preferred substrate. | 0.647 |
