node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dltA | oatA | BSU38500 | BSU27140 | D-alanine:D-alanyl-carrier protein ligase; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP [...] | Peptidoglycan O-acetyltransferase; Evidence 1a: Function experimentally demonstrated in the studied strain; enzyme. | 0.875 |
dltA | sigV | BSU38500 | BSU27120 | D-alanine:D-alanyl-carrier protein ligase; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP [...] | RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma(V)); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Positively regulates the expression of proteins involved in stress responses against bacitracin, paraquat and tellurite. Belongs to the sigma-70 factor family. ECF subfamily. | 0.751 |
dltA | yrhK | BSU38500 | BSU27150 | D-alanine:D-alanyl-carrier protein ligase; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP [...] | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | 0.480 |
oatA | dltA | BSU27140 | BSU38500 | Peptidoglycan O-acetyltransferase; Evidence 1a: Function experimentally demonstrated in the studied strain; enzyme. | D-alanine:D-alanyl-carrier protein ligase; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP [...] | 0.875 |
oatA | rseP | BSU27140 | BSU16560 | Peptidoglycan O-acetyltransferase; Evidence 1a: Function experimentally demonstrated in the studied strain; enzyme. | Regulator of sigma-W protease RasP; Is responsible for site-2 cleavage of the RsiW anti-sigma factor. This results, after a third proteolytic step catalyzed by the ClpXP protease, in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor. Can also cleave liberated signal peptides of PenP and Mpr, probably within in the cell membrane. | 0.448 |
oatA | rsiV | BSU27140 | BSU27130 | Peptidoglycan O-acetyltransferase; Evidence 1a: Function experimentally demonstrated in the studied strain; enzyme. | anti-sigma(V) factor; Anti-sigma factor for SigV. Negatively regulates SigV activity through direct interaction. | 0.894 |
oatA | sigV | BSU27140 | BSU27120 | Peptidoglycan O-acetyltransferase; Evidence 1a: Function experimentally demonstrated in the studied strain; enzyme. | RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma(V)); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Positively regulates the expression of proteins involved in stress responses against bacitracin, paraquat and tellurite. Belongs to the sigma-70 factor family. ECF subfamily. | 0.968 |
oatA | yrhK | BSU27140 | BSU27150 | Peptidoglycan O-acetyltransferase; Evidence 1a: Function experimentally demonstrated in the studied strain; enzyme. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | 0.902 |
rpoB | sigM | BSU01070 | BSU09520 | RNA polymerase (beta subunit); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma(M)); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by a cognate anti-sigma factor (YhdL) until released. This sigma factor is involved in the maintenance of membrane and cell wall integrity in response to environmental stresses including salt, acid, ethanol and antibiotics stress. Partially regulates transcription from a number of genes including disA. | 0.556 |
rpoB | sigV | BSU01070 | BSU27120 | RNA polymerase (beta subunit); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma(V)); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Positively regulates the expression of proteins involved in stress responses against bacitracin, paraquat and tellurite. Belongs to the sigma-70 factor family. ECF subfamily. | 0.598 |
rpoB | sigY | BSU01070 | BSU38700 | RNA polymerase (beta subunit); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma-Y); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Positively regulates the expression of the sigY-yxlCDEFG operon upon nitrogen starvation. Also positively regulates ybgB. | 0.532 |
rpoB | sigZ | BSU01070 | BSU26840 | RNA polymerase (beta subunit); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma-Z); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | 0.532 |
rseP | oatA | BSU16560 | BSU27140 | Regulator of sigma-W protease RasP; Is responsible for site-2 cleavage of the RsiW anti-sigma factor. This results, after a third proteolytic step catalyzed by the ClpXP protease, in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor. Can also cleave liberated signal peptides of PenP and Mpr, probably within in the cell membrane. | Peptidoglycan O-acetyltransferase; Evidence 1a: Function experimentally demonstrated in the studied strain; enzyme. | 0.448 |
rseP | rsiW | BSU16560 | BSU01740 | Regulator of sigma-W protease RasP; Is responsible for site-2 cleavage of the RsiW anti-sigma factor. This results, after a third proteolytic step catalyzed by the ClpXP protease, in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor. Can also cleave liberated signal peptides of PenP and Mpr, probably within in the cell membrane. | anti-sigma(W) factor; The anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-W (SigW). Holds SigW, its cognate ECF sigma factor, in an inactive form until released by regulated intramembrane proteolysis (RIP). SigW and RsiW mediate cell response to cell wall stress. RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, PrsW) , then within the membrane itself (site-2 protease, S2P [...] | 0.979 |
rseP | sigV | BSU16560 | BSU27120 | Regulator of sigma-W protease RasP; Is responsible for site-2 cleavage of the RsiW anti-sigma factor. This results, after a third proteolytic step catalyzed by the ClpXP protease, in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor. Can also cleave liberated signal peptides of PenP and Mpr, probably within in the cell membrane. | RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma(V)); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Positively regulates the expression of proteins involved in stress responses against bacitracin, paraquat and tellurite. Belongs to the sigma-70 factor family. ECF subfamily. | 0.757 |
rsiV | oatA | BSU27130 | BSU27140 | anti-sigma(V) factor; Anti-sigma factor for SigV. Negatively regulates SigV activity through direct interaction. | Peptidoglycan O-acetyltransferase; Evidence 1a: Function experimentally demonstrated in the studied strain; enzyme. | 0.894 |
rsiV | sigV | BSU27130 | BSU27120 | anti-sigma(V) factor; Anti-sigma factor for SigV. Negatively regulates SigV activity through direct interaction. | RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma(V)); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Positively regulates the expression of proteins involved in stress responses against bacitracin, paraquat and tellurite. Belongs to the sigma-70 factor family. ECF subfamily. | 0.996 |
rsiV | yrhK | BSU27130 | BSU27150 | anti-sigma(V) factor; Anti-sigma factor for SigV. Negatively regulates SigV activity through direct interaction. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | 0.783 |
rsiW | rseP | BSU01740 | BSU16560 | anti-sigma(W) factor; The anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-W (SigW). Holds SigW, its cognate ECF sigma factor, in an inactive form until released by regulated intramembrane proteolysis (RIP). SigW and RsiW mediate cell response to cell wall stress. RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, PrsW) , then within the membrane itself (site-2 protease, S2P [...] | Regulator of sigma-W protease RasP; Is responsible for site-2 cleavage of the RsiW anti-sigma factor. This results, after a third proteolytic step catalyzed by the ClpXP protease, in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor. Can also cleave liberated signal peptides of PenP and Mpr, probably within in the cell membrane. | 0.979 |
rsiW | sigM | BSU01740 | BSU09520 | anti-sigma(W) factor; The anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-W (SigW). Holds SigW, its cognate ECF sigma factor, in an inactive form until released by regulated intramembrane proteolysis (RIP). SigW and RsiW mediate cell response to cell wall stress. RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, PrsW) , then within the membrane itself (site-2 protease, S2P [...] | RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma(M)); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by a cognate anti-sigma factor (YhdL) until released. This sigma factor is involved in the maintenance of membrane and cell wall integrity in response to environmental stresses including salt, acid, ethanol and antibiotics stress. Partially regulates transcription from a number of genes including disA. | 0.707 |