STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yrzLConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; Belongs to the UPF0297 family. (88 aa)    
Predicted Functional Partners:
yrrK
Putative Holliday junction resolvase; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
 
    0.983
yrzB
Putative anti-sigma factor; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator; Belongs to the UPF0473 family.
 
  
 0.936
ylxM
Conserved hypothetical protein; Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.
 
  
 0.818
yloU
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 16014871, 17114254; Belongs to the asp23 family.
  
  
 0.774
ypiB
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 16847875; Belongs to the UPF0302 family.
      
 0.746
prkC
Protein kinase; Protein kinase that is responsible for triggering spore germination in response to muropeptides, signaling bacteria to exit dormancy. PrkC is thus a germination receptor that binds peptidoglycan fragments containing m-Dpm (meso-diaminopimelate), which act as spore germinants. Autophosphorylates and phosphorylates EF-G (elongation factor G, fusA); the latter modification is likely necessary for germination in response to peptidoglycan. Another group did not detect phosphorylation of EF-G. PrkC is a substrate in vitro of the cotranscribed phosphatase PrpC, which suggests [...]
  
  
 0.744
yqhY
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 16014871, 17114254; Belongs to the asp23 family.
 
  
 0.727
trmK
tRNA (adenine(22)-N(1))-methyltransferase; Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 22 (m1A22) in tRNA.
  
     0.723
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
  
    0.722
yyzM
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function.
  
     0.707
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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