| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| bofC | csbX | BSU27750 | BSU27760 | Bypass of forespore C, intercompartmental signaling factor; Inhibits the SpoIVB zymogen from undergoing autocatalytic activation by an unknown mechanism, and in this way plays a role in the sigma-K checkpoint of sporulation. | Putative permease; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. CsbX subfamily. | 0.894 |
| bofC | queA | BSU27750 | BSU27720 | Bypass of forespore C, intercompartmental signaling factor; Inhibits the SpoIVB zymogen from undergoing autocatalytic activation by an unknown mechanism, and in this way plays a role in the sigma-K checkpoint of sporulation. | S-adenosylmethionine tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | 0.510 |
| bofC | ruvA | BSU27750 | BSU27740 | Bypass of forespore C, intercompartmental signaling factor; Inhibits the SpoIVB zymogen from undergoing autocatalytic activation by an unknown mechanism, and in this way plays a role in the sigma-K checkpoint of sporulation. | Holliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.555 |
| bofC | ruvB | BSU27750 | BSU27730 | Bypass of forespore C, intercompartmental signaling factor; Inhibits the SpoIVB zymogen from undergoing autocatalytic activation by an unknown mechanism, and in this way plays a role in the sigma-K checkpoint of sporulation. | Holliday junction DNA helicase, ATP-dependent component; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity). Stimulates the resolution of Holliday junctions by RecU. | 0.562 |
| bofC | tgt | BSU27750 | BSU27710 | Bypass of forespore C, intercompartmental signaling factor; Inhibits the SpoIVB zymogen from undergoing autocatalytic activation by an unknown mechanism, and in this way plays a role in the sigma-K checkpoint of sporulation. | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] | 0.478 |
| bofC | yrbF | BSU27750 | BSU27700 | Bypass of forespore C, intercompartmental signaling factor; Inhibits the SpoIVB zymogen from undergoing autocatalytic activation by an unknown mechanism, and in this way plays a role in the sigma-K checkpoint of sporulation. | Component of the preprotein translocase; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. | 0.437 |
| bofC | yrzS | BSU27750 | BSU27729 | Bypass of forespore C, intercompartmental signaling factor; Inhibits the SpoIVB zymogen from undergoing autocatalytic activation by an unknown mechanism, and in this way plays a role in the sigma-K checkpoint of sporulation. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | 0.553 |
| csbX | bofC | BSU27760 | BSU27750 | Putative permease; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. CsbX subfamily. | Bypass of forespore C, intercompartmental signaling factor; Inhibits the SpoIVB zymogen from undergoing autocatalytic activation by an unknown mechanism, and in this way plays a role in the sigma-K checkpoint of sporulation. | 0.894 |
| csbX | ruvA | BSU27760 | BSU27740 | Putative permease; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. CsbX subfamily. | Holliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.405 |
| csbX | ruvB | BSU27760 | BSU27730 | Putative permease; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. CsbX subfamily. | Holliday junction DNA helicase, ATP-dependent component; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity). Stimulates the resolution of Holliday junctions by RecU. | 0.402 |
| csbX | yrzS | BSU27760 | BSU27729 | Putative permease; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. CsbX subfamily. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | 0.402 |
| pcrA | rsmB | BSU06610 | BSU15740 | ATP-dependent DNA helicase; DNA helicase used for plasmid rolling-circle replication and also involved in UV repair. | RNA-binding Sun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.732 |
| pcrA | ruvA | BSU06610 | BSU27740 | ATP-dependent DNA helicase; DNA helicase used for plasmid rolling-circle replication and also involved in UV repair. | Holliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.610 |
| pcrA | ruvB | BSU06610 | BSU27730 | ATP-dependent DNA helicase; DNA helicase used for plasmid rolling-circle replication and also involved in UV repair. | Holliday junction DNA helicase, ATP-dependent component; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity). Stimulates the resolution of Holliday junctions by RecU. | 0.624 |
| pcrA | yrzS | BSU06610 | BSU27729 | ATP-dependent DNA helicase; DNA helicase used for plasmid rolling-circle replication and also involved in UV repair. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | 0.636 |
| polX | ruvA | BSU28590 | BSU27740 | DNA polymerase/3'-5' exonuclease X; Strictly DNA-template-directed DNA polymerase, preferentially acting on DNA structures containing gaps from one to a few nucleotides and bearing a phosphate group at the 5' end of the downstream DNA. The fact that PolX is able to conduct filling of a single-nucleotide gap, allowing further sealing of the resulting nick by a DNA ligase, points to a putative role in base excision repair (BER) during the B.subtilis life cycle. Moreover, also possesses a 3'-5' exonuclease activity able to edit unpaired 3'-termini in a gapped DNA substrate and likely invo [...] | Holliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.518 |
| polX | yrzS | BSU28590 | BSU27729 | DNA polymerase/3'-5' exonuclease X; Strictly DNA-template-directed DNA polymerase, preferentially acting on DNA structures containing gaps from one to a few nucleotides and bearing a phosphate group at the 5' end of the downstream DNA. The fact that PolX is able to conduct filling of a single-nucleotide gap, allowing further sealing of the resulting nick by a DNA ligase, points to a putative role in base excision repair (BER) during the B.subtilis life cycle. Moreover, also possesses a 3'-5' exonuclease activity able to edit unpaired 3'-termini in a gapped DNA substrate and likely invo [...] | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | 0.437 |
| queA | bofC | BSU27720 | BSU27750 | S-adenosylmethionine tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | Bypass of forespore C, intercompartmental signaling factor; Inhibits the SpoIVB zymogen from undergoing autocatalytic activation by an unknown mechanism, and in this way plays a role in the sigma-K checkpoint of sporulation. | 0.510 |
| queA | rsmB | BSU27720 | BSU15740 | S-adenosylmethionine tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | RNA-binding Sun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.620 |
| queA | ruvA | BSU27720 | BSU27740 | S-adenosylmethionine tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | Holliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.913 |