STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yrzFPutative serine/threonine-protein kinase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (215 aa)    
Predicted Functional Partners:
yrzH
Hypothetical protein; Evidence 5: No homology to any previously reported sequences.
   
  
 0.915
yhbF
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function.
      
 0.900
yqgL
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function.
      
 0.684
yfhJ
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function.
  
    0.594
yfkF
Putative efflux transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter.
      
 0.561
prkA
Serine protein kinase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the PrkA family.
      
 0.561
kapB
Factor required for KinB signal transduction and activation of the phosphorelay to sporulation; May play a role in the activation or the expression of KinB.
  
    0.558
nfrAA
FMN-containing NADPH-linked nitro/flavin reductase; Reduces FMNH(2) to FMN, with NADPH as reductant. It also reduces nitroaromatic compounds, quinones and azo dyes.
   
    0.529
ywnF
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function.
   
    0.502
mecA
Adaptor protein controlling oligomerization of the AAA+ protein ClpC; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC.
   
    0.501
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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