comC protein (Bacillus subtilis 168) - STRING interaction network

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comC

Membrane protease and transmethylase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue; Belongs to the peptidase A24 family. (248 aa)

Predicted Functional Partners:

comGB

0.995

comGA

0.995

comGD

0.983

comGC

0.982

comEA

0.981

comEC

0.979

comGF

0.969

comGE

0.966

comFA

0.964

comGG

0.948

Your Current Organism:

Bacillus subtilis 168

NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
comC	comEA	BSU28070	BSU25590	Membrane protease and transmethylase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue; Belongs to the peptidase A24 family.	Membrane bound high-affinity DNA-binding receptor; Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect.	0.981
comC	comEC	BSU28070	BSU25570	Membrane protease and transmethylase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue; Belongs to the peptidase A24 family.	DNA channel for uptake in competent cells; The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding; To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI.	0.979
comC	comFA	BSU28070	BSU35470	Membrane protease and transmethylase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue; Belongs to the peptidase A24 family.	Helicase competence protein; Involved in transformation (competence for DNA uptake). Required for DNA uptake but not for binding. May provide the driving force for transport of DNA through an aqueous channel. Belongs to the helicase family.	0.964
comC	comGA	BSU28070	BSU24730	Membrane protease and transmethylase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue; Belongs to the peptidase A24 family.	Membrane associated ATPase for DNA competence; Required for uptake of DNA by competent cells.	0.995
comC	comGB	BSU28070	BSU24720	Membrane protease and transmethylase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue; Belongs to the peptidase A24 family.	Membrane platform component of the DNA transport machinery; Required for transformation and DNA binding. Belongs to the GSP F family.	0.995
comC	comGC	BSU28070	BSU24710	Membrane protease and transmethylase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue; Belongs to the peptidase A24 family.	Pilin-like component of the DNA transport membrane platform; Required for transformation and DNA binding. Belongs to the ComGC family.	0.982
comC	comGD	BSU28070	BSU24700	Membrane protease and transmethylase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue; Belongs to the peptidase A24 family.	Membrane component of the DNA transport platform; Required for transformation and DNA binding.	0.983
comC	comGE	BSU28070	BSU24690	Membrane protease and transmethylase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue; Belongs to the peptidase A24 family.	Component of the DNA transport platform; Required for transformation and DNA binding.	0.966
comC	comGF	BSU28070	BSU24680	Membrane protease and transmethylase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue; Belongs to the peptidase A24 family.	Component of the DNA transport platform; Required for transformation and DNA binding.	0.969
comC	comGG	BSU28070	BSU24670	Membrane protease and transmethylase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue; Belongs to the peptidase A24 family.	Component of the DNA transport platform; Required for transformation and DNA binding.	0.948
comEA	comC	BSU25590	BSU28070	Membrane bound high-affinity DNA-binding receptor; Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect.	Membrane protease and transmethylase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue; Belongs to the peptidase A24 family.	0.981
comEA	comEC	BSU25590	BSU25570	Membrane bound high-affinity DNA-binding receptor; Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect.	DNA channel for uptake in competent cells; The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding; To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI.	0.999
comEA	comFA	BSU25590	BSU35470	Membrane bound high-affinity DNA-binding receptor; Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect.	Helicase competence protein; Involved in transformation (competence for DNA uptake). Required for DNA uptake but not for binding. May provide the driving force for transport of DNA through an aqueous channel. Belongs to the helicase family.	0.998
comEA	comGA	BSU25590	BSU24730	Membrane bound high-affinity DNA-binding receptor; Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect.	Membrane associated ATPase for DNA competence; Required for uptake of DNA by competent cells.	0.996
comEA	comGB	BSU25590	BSU24720	Membrane bound high-affinity DNA-binding receptor; Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect.	Membrane platform component of the DNA transport machinery; Required for transformation and DNA binding. Belongs to the GSP F family.	0.987
comEA	comGC	BSU25590	BSU24710	Membrane bound high-affinity DNA-binding receptor; Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect.	Pilin-like component of the DNA transport membrane platform; Required for transformation and DNA binding. Belongs to the ComGC family.	0.983
comEA	comGD	BSU25590	BSU24700	Membrane bound high-affinity DNA-binding receptor; Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect.	Membrane component of the DNA transport platform; Required for transformation and DNA binding.	0.979
comEA	comGE	BSU25590	BSU24690	Membrane bound high-affinity DNA-binding receptor; Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect.	Component of the DNA transport platform; Required for transformation and DNA binding.	0.931
comEA	comGF	BSU25590	BSU24680	Membrane bound high-affinity DNA-binding receptor; Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect.	Component of the DNA transport platform; Required for transformation and DNA binding.	0.930
comEA	comGG	BSU25590	BSU24670	Membrane bound high-affinity DNA-binding receptor; Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect.	Component of the DNA transport platform; Required for transformation and DNA binding.	0.927

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