Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
cstACarbon starvation-induced membrane protein; Involved in peptide utilization. Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family. (598 aa)    
Predicted Functional Partners:
csrA
Carbon storage regulator; A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'- UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Represses expression of flagellin (hag) in a post-transcriptional fashion. Specifically binds to 2 sites in the 5'-UTR of hag mRNA in a cooperative fashion; the second site overlaps the Shine-Dalgarno sequence and prevents 30S ribosomal subunit binding. Mutation of either binding site abolishes CsrA regulation of hag expression. Repressio [...]
      
 0.894
ysfE
Hypothetical protein; Evidence 5: No homology to any previously reported sequences.
  
    0.844
lytS
Two-component sensor histidine kinase [LytT]; Member of the two-component regulatory system LytS/LytT that probably regulates genes involved in cell wall metabolism.
 
  
 0.765
glgC
Glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) subunit alpha; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
   
  
 0.758
hfq
Hfq RNA chaperone; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family.
      
 0.735
rbsC
Ribose ABC transporter (permease); Part of the ABC transporter complex RbsABC involved in ribose import. Probably responsible for the translocation of the substrate across the membrane.
   
    0.724
rbsR
Transcriptional regulator (LacI family); Transcriptional repressor for the ribose rbsDACBK operon.
   
  
 0.717
yrkI
Putative sulfur-carrier protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier; Belongs to the sulfur carrier protein TusA family.
      
 0.696
rbsB
Ribose ABC transporter (ribose-binding lipoprotein); Part of the ABC transporter complex RbsABC involved in ribose import. Binds ribose.
   
  
 0.669
acoR
Transcriptional regulator; Acts as a transcriptional activator of the acoABCL operon encoding the acetoin dehydrogenase complex.
  
    0.660
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.