STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ytxGConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 8733232. (140 aa)    
Predicted Functional Partners:
ytxH
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 16291680, 8733232; To C.plantagineum desiccation-related protein clone PCC3- 06.
  
  
 0.996
ytxJ
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 8733232.
  
  
 0.917
rsbW
Switch protein/serine kinase and anti-sigma factor (inhibitory sigma-B binding protein); Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B).
 
    0.871
ytpQ
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 12719520, 21949854; Belongs to the UPF0354 family.
 
    0.823
sigB
RNA polymerase sigma-37 factor (sigma(B)); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Sigma B is not essential for sporulation; rather it is required for maximal expression of ctc and csbA which are transcribed in the early stationary phase under conditions inimical to sporulation. May play a role in the ability of the bacterium to adapt to various stresses but is not essential for its survival under these conditions. Positively regulates expression of its own operon; Belongs to the sigma-70 fac [...]
  
    0.817
ydaG
Putative general stress protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor.
   
  
 0.755
mgsR
Transcriptional regulator of stress; Regulates transcription of a subregulon within the general stress response. Exerts positive and negative effects in response to ethanol stress.
  
  
 0.748
rsbV
Anti-anti-sigma factor (antagonist of RsbW); Positive regulator of sigma-B activity. Non-phosphorylated RsbV binds to RsbW, preventing its association with sigma-B. When phosphorylated, releases RsbW, which is then free to complex with and inactivate sigma-B.
 
    0.737
ybcM
Putative enzyme; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme.
  
     0.723
dps
DNA-protecting protein, ferritin; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type e: enzyme.
   
    0.723
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.