STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
bceSSensor protein BceS; Member of the two-component regulatory system BceS/BceR involved in the regulation of bacitracin resistance. Activates BceR in response to extracellular bacitracin. (334 aa)    
Predicted Functional Partners:
bceR
Sensory transduction protein BceR; Member of the two-component regulatory system BceS/BceR involved in the regulation of bacitracin resistance. When activated by BceS, binds to the upstream region of the bceAB promoter and up- regulates the expression of these two genes.
 0.999
bceB
ABC transporter (permease); Part of the ABC transporter complex BceAB (TC 3.A.1.123.5) involved in bacitracin export; Belongs to the ABC-4 integral membrane protein family.
 
  
 0.992
bceA
Bacitracin ABC efflux transporter (ATP-binding protein); Part of the ABC transporter complex BceAB (TC 3.A.1.123.5) involved in bacitracin export. Responsible for energy coupling to the transport system.
 
 
 0.991
dhbE
2,3-dihydroxybenzoate-AMP ligase; Involved in the biosynthesis of the catecholic siderophore bacillibactin. Catalyzes the activation of the carboxylate group of 2,3-dihydroxy-benzoate (DHB), via ATP-dependent PPi exchange reactions, to the acyladenylate.
      
 0.845
yvcP
Two-component response regulator [YvcQ]; Member of the two-component regulatory system YvcQ/YvcP.
   0.803
yxdJ
Two-component response regulator [YxdK]; Probable member of the two-component regulatory system YxdK/YxdJ. Positively regulates the expression of the yxdLMyxeA operon by direct interaction with its promoter region. Could also indirectly regulate the expression of the dlt operon.
   0.748
yvcS
Putative ABC transporter (permease); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter.
 
  
 0.697
ytrF
Metabolite permease; Part of the ABC transporter complex YtrBCDEF that plays a role in acetoin utilization during stationary phase and sporulation.
 
    0.626
yxdM
ABC transporter (permease); Part of the ABC transporter complex YxdLM which could be involved in peptide resistance; Belongs to the ABC-4 integral membrane protein family.
 
   
 0.623
ycbL
Two-component response regulator [YcbM]; Member of the two-component regulatory system YcbM/YcbL.
 
 0.612
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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