Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
bceRSensory transduction protein BceR; Member of the two-component regulatory system BceS/BceR involved in the regulation of bacitracin resistance. When activated by BceS, binds to the upstream region of the bceAB promoter and up- regulates the expression of these two genes. (231 aa)    
Predicted Functional Partners:
bceS
Sensor protein BceS; Member of the two-component regulatory system BceS/BceR involved in the regulation of bacitracin resistance. Activates BceR in response to extracellular bacitracin.
 0.999
bceB
ABC transporter (permease); Part of the ABC transporter complex BceAB (TC 3.A.1.123.5) involved in bacitracin export; Belongs to the ABC-4 integral membrane protein family.
  
 0.997
bceA
Bacitracin ABC efflux transporter (ATP-binding protein); Part of the ABC transporter complex BceAB (TC 3.A.1.123.5) involved in bacitracin export. Responsible for energy coupling to the transport system.
 
  
 0.997
yxdM
ABC transporter (permease); Part of the ABC transporter complex YxdLM which could be involved in peptide resistance; Belongs to the ABC-4 integral membrane protein family.
 
   
 0.876
yxdK
Two-component sensor histidine kinase [YxdJ]; Probable member of the two-component regulatory system YxdK/YxdJ. May activate YxdJ in response to the antibacterial protein LL-37.
   0.823
yvcS
Putative ABC transporter (permease); Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter.
 
  
 0.811
yvcQ
Two-component sensor histidine kinase [YvcP]; Member of the two-component regulatory system YvcQ/YvcP. Probably activates YvcP by phosphorylation.
 
   0.799
bcrC
Undecaprenyl pyrophosphate phosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the BcrC/YbjG family.
   
  
 0.775
ykoH
Two-component sensor histidine kinase [YkoG]; Probable member of the two-component regulatory system YkoH/YkoG. Potentially phosphorylates YkoG.
 
 
 0.759
mprF
Phosphatidylglycerol lysyltransferase involved in lysinylation of phospholipids; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge. LPG synthesis contributes to the resistance to cationic antimicrobial peptides (CAMPs) and likely protects B.subtilis against its own CAMPs and against those produced by competiting microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with po [...]
   
  
 0.756
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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