STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ytiBCarbonic anhydrase; Reversible hydration of carbon dioxide. (187 aa)    
Predicted Functional Partners:
ythA
Putative cytochrome bd menaquinol oxidase subunit I; May have a role in sporulation. Can compensate for the loss of cytochrome aa3; Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
     
 0.941
yvdA
Putative carbonic anhydrase; Reversible hydration of carbon dioxide.
  
  
0.905
ytoA
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; Belongs to the transferase hexapeptide repeat family.
    
 
 0.679
yrhG
Putative formate/nitrite transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter.
  
    0.597
ywcJ
Formate/nitrite transporter; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type t: transporter.
  
    0.597
rpmEB
Ribosomal protein L31; While neither of the L31 paralogs is essential, this protein does not seem to function as the main L31 protein. Has a higher affinity for 70S ribosomes than the zinc-containing L31 paralog; is able to displace it to varying extents, even under zinc-replete conditions.
  
    0.554
purR
Transcriptional regulator of the purine biosynthesis operon; Controls the transcription of the pur operon for purine biosynthetic genes, binds to the control region of the operon. DNA binding is inhibited by 5-phosphoribosyl 1-pyrophosphate; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
   
    0.462
xpt
Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so that it can be reused for RNA or DNA synthesis; Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
   
    0.457
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
   
    0.457
ybcF
Putative carbonic anhydrase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the beta-class carbonic anhydrase family.
  
   
0.443
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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