STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mntBManganese ABC transporter (ATP-binding protein); Probably part of the ABC transporter complex MntABCD involved in manganese import. Probably responsible for energy coupling to the transport system. (250 aa)    
Predicted Functional Partners:
mntD
Manganese ABC transporter (permease); Probably part of the ABC transporter complex MntABCD involved in manganese import. Probably responsible for the translocation of the substrate across the membrane; Belongs to the ABC-3 integral membrane protein family.
 0.999
mntC
Manganese ABC transporter (permease); Probably part of the ABC transporter complex MntABCD involved in manganese import. Probably responsible for the translocation of the substrate across the membrane; Belongs to the ABC-3 integral membrane protein family.
 0.999
mntA
Manganese ABC transporter (manganese binding lipoprotein); Probably part of the ABC transporter complex MntABCD involved in manganese import.
 
 
 0.999
znuB
High affinity Zn(II) ABC transporter (permease); Part of the high-affinity ABC transporter complex ZnuABC involved in zinc import (Probable). Responsible for the translocation of the substrate across the membrane (By similarity). ZnuABC-mediated zinc transport is required for comF expression and competence development.
 0.964
mntH
Manganese transporter; H(+)-stimulated, divalent metal cation uptake system. Involved in manganese uptake. Can probably also transport cadmium, cobalt, copper and zinc, but not iron. May be the predominant transporter of manganese during logarithmic phase growth.
  
  
 0.956
znuA
Zn(II)-binding lipoprotein; Part of the high-affinity ABC transporter complex ZnuABC involved in zinc import (Probable). ZnuABC-mediated zinc transport is required for comF expression and competence development.
 
  
 0.950
mntR
Transcriptional regulator (DtxR family); Central regulator of manganese homeostasis that regulates the expression of both manganese uptake and efflux systems. In the presence of high levels of manganese, it mediates repression of the manganese uptake systems MntH and MntABCD and activation of the efflux systems MneP and MneS. Binds with high affinity to the regulatory regions of its target genes. The manganese concentration required for activation of efflux is higher than that for repression of uptake ; Belongs to the DtxR/MntR family.
 
   
 0.816
yrpE
Putative lipoprotein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp: lipoprotein; Belongs to the calycin superfamily. ZinT family.
  
  
 0.762
yknZ
Putative permease; Part of an unusual four-component transporter, which is required for protection against the killing factor SdpC (sporulation- delaying protein).
 
    0.748
mdxE
Maltose/maltodextrin-binding lipoprotein; Part of the ABC transporter complex involved in maltodextrin import. Binds maltodextrin. Can also bind maltose with low affinity, but is not involved in its uptake; Belongs to the bacterial solute-binding protein 1 family.
     
 0.711
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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