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comA protein (Bacillus subtilis) - STRING interaction network
"comA" - Transcriptional regulatory protein ComA in Bacillus subtilis
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
comATranscriptional regulatory protein ComA; Response regulator in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Regulates directly the expression of over 20 genes, including genes of the srfA operon, degQ, rapA, rapC, rapE, rapF, etc. Regulates indirectly, through the regulation of comK transcription, the expression of late competence genes (214 aa)    
Predicted Functional Partners:
comP
Sensor histidine kinase ComP; Sensor in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Plays a role in sporulation, at least partly interchangeable with that of SpoIIJ. Probably activates ComA by phosphorylation (769 aa)
 
  0.994
rapF
Response regulator aspartate phosphatase F; Evidence 1a- Function experimentally demonstrated in the studied strain; Product type e- enzyme (381 aa)
       
  0.988
yuxO
Putative esterase ComA2; Is not required for competence (126 aa)
   
   
  0.973
comQ
Competence regulatory protein ComQ; Involved in the maturation of ComX, part of a major quorum-sensing system that regulates the development of genetic competence (299 aa)
 
     
  0.831
rapC
Response regulator aspartate phosphatase C; Evidence 1a- Function experimentally demonstrated in the studied strain; Product type e- enzyme; Belongs to the RAP family (382 aa)
         
  0.828
rapG
Response regulator aspartate phosphatase G; Evidence 1a- Function experimentally demonstrated in the studied strain; Product type e- enzyme (365 aa)
         
  0.806
rapH
Response regulator aspartate phosphatase H; Evidence 1a- Function experimentally demonstrated in the studied strain; Product type e- enzyme; Belongs to the RAP family (376 aa)
         
  0.806
rapK
Response regulator aspartate phosphatase K; Evidence 7- Gene remnant; Product type h - extrachromosomal origin; Belongs to the RAP family (371 aa)
         
    0.800
yxjM
Sensor histidine kinase YxjM; Probable member of the two-component regulatory system YxjM/YxjL. May activate YxjL by phosphorylation (406 aa)
 
  0.790
liaS
Sensor histidine kinase LiaS; Member of the two-component regulatory system LiaS/LiaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also involved in response to cationic antimicrobial peptides and secretion stress. Activates probably LiaR by phosphorylation (360 aa)
 
  0.784
Your Current Organism:
Bacillus subtilis
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis, Bacillus subtilis 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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