Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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comXCompetence pheromone precursor (pheromone peptide aa 46->55, geranyl-modified); Part of a major quorum-sensing system that regulates the development of genetic competence. Acts through the activation of the two-component regulatory system ComP/ComA composed of a sensor histidine kinase, ComP, and a response regulator, ComA, that regulates directly the transcription of over 20 genes. Transport through the membrane may involve Spo0K. Under certain conditions plays a role in sporulation. (55 aa)    
Predicted Functional Partners:
comP
Two-component sensor histidine kinase; Sensor in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Plays a role in sporulation, at least partly interchangeable with that of SpoIIJ. Probably activates ComA by phosphorylation.
  
 
 0.998
comQ
Isoprenyl transferase (pre-ComX modification); Involved in the maturation of ComX, part of a major quorum- sensing system that regulates the development of genetic competence.
  
  
 0.995
yuxO
Putative esterase; Is not required for competence.
  
  
 0.960
comS
Regulator of genetic competence; Required for the development of competence.
   
  
 0.923
pnpA
Polynucleotide phosphorylase (PNPase); Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. Necessary for competence development in Bacillus subtilis. May be necessary for modification of the srfA transcript (stabilization or translation activation).
      
 0.903
phrC
Phosphatase RapC inhibitor; Inhibitor of the activity of phosphatase RapC; Belongs to the phr family.
   
  
 0.782
sigX
RNA polymerase ECF(extracytoplasmic function)-type sigma factor sigma(X); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. May be involved in the regulation of iron metabolism; Belongs to the sigma-70 factor family. ECF subfamily.
      
 0.770
degQ
Pleiotropic regulator; Stimulates the phosphotransfer from phospho-DegS to DegU. Affects protease and levansucrose production.
  
  
 0.755
comGD
Membrane component of the DNA transport platform; Required for transformation and DNA binding.
      
 0.745
srfAA
Surfactin synthetase; This protein is a multifunctional enzyme able to activate and polymerize the amino acids Leu, Glu, Asp and Val. Activation sites for these AA consist of individual domains.
   
  
 0.716
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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