Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
yuxHPutative phosphodiesterase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (409 aa)    
Predicted Functional Partners:
ykoW
Putative sensor diguanylate cyclase; Probable signaling protein whose physiological role is not yet known.
 
  
 0.939
ytrP
Putative diguanylate cyclase-related enzyme; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme.
 
   
 0.923
yhcK
Putative diguanylate cyclase or phosphodiesterase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme.
  
  
 0.910
cdnD
Phosphodiesterase acting on cyclic dinucleotides; Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP) and to a much lesser extent against cyclic-di-GMP (c-di-GMP) in the DHH/DHHA1 domains. Also has ATPase activity, probably via the GGDEF domain. Overexpression leads to increased sensitivity to methyl methanesulfonate (MMS) and H(2)O(2). Overexpression leads to extreme sensitivity to the beta-lactam antibiotic cefuroxime (CEF), probably dependent on PDE activity. May monitor cellular heme or NO levels. In B.subtilis c-di-AMP is a second messenger that mediates growth, [...]
      
 0.907
ymdB
Putative hydrolase involved in biofilm formation; Plays a central, regulatory role in the late adaptive responses and affects the levels of many genes. May act via regulation of cAMP levels. Decreases the expression of motility genes and induces genes involved in biofilm formation, by controlling the expression of SlrR. Required for formation of intercellular nanotubes that bridge neighboring cells to allow molecular exchange. Plays a key role in directing the early stages of colony development. In vitro, has a metal-dependent phosphodiesterase activity against 2',3'-cAMP and 2',3'-cGM [...]
      
 0.880
phoD
Alkaline phosphatase D; Evidence 1a: Function experimentally demonstrated in the studied strain; enzyme.
      
 0.879
ypfA
Putative cyclic diGMP binding protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator.
  
  
 0.861
ykuI
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function.
 
   
 0.843
ydaK
Putative membrane protein with diguanylate cyclase domain; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component.
 
   
 0.829
tatCD
Component of the twin-arginine pre-protein translocation pathway; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Required for PhoD secretion. TatCd promotes membrane localization of TatAd via domain specific interactions. TatCd is required for stabile production of TatAd as well as for its maintenance; Belongs to the TatC family.
     
 0.718
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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