node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aprE | paiB | BSU10300 | BSU32140 | Serine alkaline protease (subtilisin E); Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides; Belongs to the peptidase S8 family. | Putative enzyme; Involved in the reduction of extracellular and cell- associated protease levels, as well as in the reduced levels of alpha- amylase, levansucrase, alkaline phosphatase and sporulation inhibition, when present in high copy number. | 0.429 |
aprE | sacB | BSU10300 | BSU34450 | Serine alkaline protease (subtilisin E); Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides; Belongs to the peptidase S8 family. | Levansucrase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. | 0.754 |
aprE | scoC | BSU10300 | BSU09990 | Serine alkaline protease (subtilisin E); Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides; Belongs to the peptidase S8 family. | HTH-type transcriptional regulator Hpr; Negative regulator of protease production and sporulation. Acts by binding directly to the promoter of protease genes (aprE and nprE), and by repressing oligopeptide permease operons (appABCDF and oppABCDF), thereby preventing uptake of oligopeptides required for initiation of sporulation. Acts with SinR as a corepressor of epr expression. | 0.737 |
paiA | paiB | BSU32150 | BSU32140 | Polyamine N-acetyltransferase; Involved in the protection against polyamine toxicity by regulating their concentration. Also could be involved in the negative control of sporulation as well as production of degradative enzymes such as alpha-amylase, levansucrase and alkaline phosphatase. Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and releases both CoA and the acetylated product. It possesses N1-acetyltransferase activity toward polyamine substrates including spermidine, spermine, aminopropylcadaverine, norspermidine, homospermidine [...] | Putative enzyme; Involved in the reduction of extracellular and cell- associated protease levels, as well as in the reduced levels of alpha- amylase, levansucrase, alkaline phosphatase and sporulation inhibition, when present in high copy number. | 0.995 |
paiA | sacB | BSU32150 | BSU34450 | Polyamine N-acetyltransferase; Involved in the protection against polyamine toxicity by regulating their concentration. Also could be involved in the negative control of sporulation as well as production of degradative enzymes such as alpha-amylase, levansucrase and alkaline phosphatase. Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and releases both CoA and the acetylated product. It possesses N1-acetyltransferase activity toward polyamine substrates including spermidine, spermine, aminopropylcadaverine, norspermidine, homospermidine [...] | Levansucrase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. | 0.474 |
paiB | aprE | BSU32140 | BSU10300 | Putative enzyme; Involved in the reduction of extracellular and cell- associated protease levels, as well as in the reduced levels of alpha- amylase, levansucrase, alkaline phosphatase and sporulation inhibition, when present in high copy number. | Serine alkaline protease (subtilisin E); Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides; Belongs to the peptidase S8 family. | 0.429 |
paiB | paiA | BSU32140 | BSU32150 | Putative enzyme; Involved in the reduction of extracellular and cell- associated protease levels, as well as in the reduced levels of alpha- amylase, levansucrase, alkaline phosphatase and sporulation inhibition, when present in high copy number. | Polyamine N-acetyltransferase; Involved in the protection against polyamine toxicity by regulating their concentration. Also could be involved in the negative control of sporulation as well as production of degradative enzymes such as alpha-amylase, levansucrase and alkaline phosphatase. Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and releases both CoA and the acetylated product. It possesses N1-acetyltransferase activity toward polyamine substrates including spermidine, spermine, aminopropylcadaverine, norspermidine, homospermidine [...] | 0.995 |
paiB | sacB | BSU32140 | BSU34450 | Putative enzyme; Involved in the reduction of extracellular and cell- associated protease levels, as well as in the reduced levels of alpha- amylase, levansucrase, alkaline phosphatase and sporulation inhibition, when present in high copy number. | Levansucrase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. | 0.624 |
paiB | scoC | BSU32140 | BSU09990 | Putative enzyme; Involved in the reduction of extracellular and cell- associated protease levels, as well as in the reduced levels of alpha- amylase, levansucrase, alkaline phosphatase and sporulation inhibition, when present in high copy number. | HTH-type transcriptional regulator Hpr; Negative regulator of protease production and sporulation. Acts by binding directly to the promoter of protease genes (aprE and nprE), and by repressing oligopeptide permease operons (appABCDF and oppABCDF), thereby preventing uptake of oligopeptides required for initiation of sporulation. Acts with SinR as a corepressor of epr expression. | 0.484 |
paiB | yhzB | BSU32140 | BSU08900 | Putative enzyme; Involved in the reduction of extracellular and cell- associated protease levels, as well as in the reduced levels of alpha- amylase, levansucrase, alkaline phosphatase and sporulation inhibition, when present in high copy number. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | 0.756 |
paiB | yuaE | BSU32140 | BSU31030 | Putative enzyme; Involved in the reduction of extracellular and cell- associated protease levels, as well as in the reduced levels of alpha- amylase, levansucrase, alkaline phosphatase and sporulation inhibition, when present in high copy number. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | 0.546 |
sacB | aprE | BSU34450 | BSU10300 | Levansucrase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. | Serine alkaline protease (subtilisin E); Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides; Belongs to the peptidase S8 family. | 0.754 |
sacB | paiA | BSU34450 | BSU32150 | Levansucrase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. | Polyamine N-acetyltransferase; Involved in the protection against polyamine toxicity by regulating their concentration. Also could be involved in the negative control of sporulation as well as production of degradative enzymes such as alpha-amylase, levansucrase and alkaline phosphatase. Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and releases both CoA and the acetylated product. It possesses N1-acetyltransferase activity toward polyamine substrates including spermidine, spermine, aminopropylcadaverine, norspermidine, homospermidine [...] | 0.474 |
sacB | paiB | BSU34450 | BSU32140 | Levansucrase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. | Putative enzyme; Involved in the reduction of extracellular and cell- associated protease levels, as well as in the reduced levels of alpha- amylase, levansucrase, alkaline phosphatase and sporulation inhibition, when present in high copy number. | 0.624 |
scoC | aprE | BSU09990 | BSU10300 | HTH-type transcriptional regulator Hpr; Negative regulator of protease production and sporulation. Acts by binding directly to the promoter of protease genes (aprE and nprE), and by repressing oligopeptide permease operons (appABCDF and oppABCDF), thereby preventing uptake of oligopeptides required for initiation of sporulation. Acts with SinR as a corepressor of epr expression. | Serine alkaline protease (subtilisin E); Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides; Belongs to the peptidase S8 family. | 0.737 |
scoC | paiB | BSU09990 | BSU32140 | HTH-type transcriptional regulator Hpr; Negative regulator of protease production and sporulation. Acts by binding directly to the promoter of protease genes (aprE and nprE), and by repressing oligopeptide permease operons (appABCDF and oppABCDF), thereby preventing uptake of oligopeptides required for initiation of sporulation. Acts with SinR as a corepressor of epr expression. | Putative enzyme; Involved in the reduction of extracellular and cell- associated protease levels, as well as in the reduced levels of alpha- amylase, levansucrase, alkaline phosphatase and sporulation inhibition, when present in high copy number. | 0.484 |
yhzB | paiB | BSU08900 | BSU32140 | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | Putative enzyme; Involved in the reduction of extracellular and cell- associated protease levels, as well as in the reduced levels of alpha- amylase, levansucrase, alkaline phosphatase and sporulation inhibition, when present in high copy number. | 0.756 |
yuaE | paiB | BSU31030 | BSU32140 | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | Putative enzyme; Involved in the reduction of extracellular and cell- associated protease levels, as well as in the reduced levels of alpha- amylase, levansucrase, alkaline phosphatase and sporulation inhibition, when present in high copy number. | 0.546 |