STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
pucHAllantoinase; Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring. (446 aa)    
Predicted Functional Partners:
pucF
Allantoate amidohydrolase; Involved in the anaerobic nitrogen utilization via the assimilation of allantoin. Catalyzes specifically the hydrolysis of allantoate to yield CO2, NH3 and S-ureidoglycine, which is unstable and readily undergoes a second deamination by S- ureidoglycine aminohydrolase AllE to yield S-ureidoglycolate and NH3 (By similarity).
 
 
 0.998
pucL
Urate oxidase with peroxide reductase N-terminal domain; Catalyzes two steps in the degradation of uric acid, i.e. the oxidation of uric acid to 5-hydroxyisourate (HIU) and the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5- ureidoimidazoline (OHCU) to (S)-allantoin.
 
 
 0.997
pyrB
Aspartate carbamoyltransferase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme.
 
 
 0.988
pucR
Transcriptional regulator of the purine degradation operon; Activates the expression of pucFG, pucH, pucI, pucJKLM and guaD, while it represses pucABCDE and its own expression. Belongs to the CdaR family.
 
  
 0.980
pucM
5-hydroxyisourate hydrolase; Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo- 4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
 
  
 0.980
pucI
Allantoin permease; Transport of allantoin.
 
  
 0.975
pucE
Xanthine dehydrogenase, iron-sulfur subunit; Oxidizes hypoxanthine and xanthine to uric acid.
 
  
 0.943
pucD
Xanthine dehydrogenase, substrate and molybdenum cofactor subunit; Oxidizes hypoxanthine and xanthine to uric acid. Belongs to the xanthine dehydrogenase family.
 
  
 0.943
pucJ
Uric acid permease; Uptake of uric acid.
  
  
 0.942
pucC
Xanthine dehydrogenase, FAD-binding subunit; Oxidizes hypoxanthine and xanthine to uric acid.
 
  
 0.940
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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