STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
pucRTranscriptional regulator of the purine degradation operon; Activates the expression of pucFG, pucH, pucI, pucJKLM and guaD, while it represses pucABCDE and its own expression. Belongs to the CdaR family. (531 aa)    
Predicted Functional Partners:
pucH
Allantoinase; Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.
 
  
 0.980
pucJ
Uric acid permease; Uptake of uric acid.
  
  
 0.979
pucF
Allantoate amidohydrolase; Involved in the anaerobic nitrogen utilization via the assimilation of allantoin. Catalyzes specifically the hydrolysis of allantoate to yield CO2, NH3 and S-ureidoglycine, which is unstable and readily undergoes a second deamination by S- ureidoglycine aminohydrolase AllE to yield S-ureidoglycolate and NH3 (By similarity).
 
  
 0.970
pucL
Urate oxidase with peroxide reductase N-terminal domain; Catalyzes two steps in the degradation of uric acid, i.e. the oxidation of uric acid to 5-hydroxyisourate (HIU) and the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5- ureidoimidazoline (OHCU) to (S)-allantoin.
 
  
 0.969
pucM
5-hydroxyisourate hydrolase; Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo- 4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
 
  
 0.965
pucI
Allantoin permease; Transport of allantoin.
 
  
 0.949
pucC
Xanthine dehydrogenase, FAD-binding subunit; Oxidizes hypoxanthine and xanthine to uric acid.
 
  
 0.932
pucD
Xanthine dehydrogenase, substrate and molybdenum cofactor subunit; Oxidizes hypoxanthine and xanthine to uric acid. Belongs to the xanthine dehydrogenase family.
 
  
 0.925
pucE
Xanthine dehydrogenase, iron-sulfur subunit; Oxidizes hypoxanthine and xanthine to uric acid.
 
  
 0.817
tnrA
Nitrogen sensing transcriptional regulator; Transcription regulator that actives the transcription of genes required for nitrogen assimilation such as nrgAB (ammonium transport), nasABCDEF (nitrate/nitrite assimilation), ureABC (urea degradation) and gabP (GABA transport), during nitrogen limitation. Also represses glnRA and gltAB in the absence of ammonium. On the contrary of the MerR members, which require longer DNA sites for high-affinity binding, TnrA requires a DNA sequence of 17 nucleotides as minimal binding site.
  
  
 0.778
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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