Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
yurZConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (125 aa)    
Predicted Functional Partners:
gdh
Glucose 1-dehydrogenase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
    0.706
sleB
Spore cortex-lytic enzyme; Could be a lytic transglycosylase. Required for spore cortex hydrolysis during germination. Interacts strongly but noncovalently with spore components.
   
    0.687
yvdQ
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function.
 
    0.637
ypeB
Spore membrane component; Required for spore cortex hydrolysis during germination. Appears to be required for either expression, localization, activation or function of SleB.
   
    0.606
spoVAC
Stage V sporulation protein AC; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process.
   
    0.605
metQ
Methionine ABC transporter, substrate binding lipoprotein; Part of the ABC transporter complex MetNPQ involved in methionine import. Binds the methionine and transfers it to the membrane-bound permease. It has also been shown to be involved in methionine sulfoxide transport (Probable); Belongs to the NlpA lipoprotein family.
       0.582
metN
Methionine ABC transporter (ATP-binding protein); Part of the ABC transporter complex MetNPQ involved in methionine import. Responsible for energy coupling to the transport system (Probable). It has also been shown to be involved in methionine sulfoxide transport. Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
       0.576
metP
Methionine ABC transporter, permease component; Part of the ABC transporter complex MetNPQ involved in methionine import. Responsible for the translocation of the substrate across the membrane (Probable). It has also been shown to be involved in methionine sulfoxide transport; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
       0.572
spoVAD
Stage V sporulation protein AD; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type cp: cell process.
   
    0.556
ycgH
Putative amino acid transporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter.
  
    0.547
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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