STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
liaRTwo-component response regulator [yvqe] responding to cell wall stress; Member of the two-component regulatory system LiaS/LiaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also involved in response to cationic antimicrobial peptides and secretion stress. LiaR regulates the transcription of the liaIHGFSR operon (211 aa)    
Predicted Functional Partners:
liaS
Two-component sensor histidine kinase [yvqc] sensing cell wall stress; Member of the two-component regulatory system LiaS/LiaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also involved in response to cationic antimicrobial peptides and secretion stress. Activates probably LiaR by phosphorylation
 0.999
liaF
Protein LiaF; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type m: membrane component
 
  
 0.995
liaH
Modulator of liaihgfsr (yvqihgfec) operon expression; Protein LiaH; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor
     
 0.956
liaI
Protein LiaI; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type t: transporter
  
  
 0.948
liaG
Conserved hypothetical protein (response to antibiotic stress); Protein LiaG; Evidence 1a: Function experimentally demonstrated in the studied strain; PubMedId: 15273097, 16816187
     
 0.932
yhdA
Oxidoreductase, nad(p)h-fmn and ferric iron reductase; Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADPH, but not NADH, as an electron donor for its activity
      
 0.881
yvlB
Conserved hypothetical protein; Uncharacterized protein YvlB; Evidence 4: Homologs of previously reported genes of unknown function
      
 0.881
yhcY
Two-component system, narl family, sensor kinase; Member of the two-component regulatory system YhcY/YhcZ. Probably activates YhcZ by phosphorylation
 
 0.876
desK
Two-component system, narl family, sensor histidine kinase desk; Member of the two-component regulatory system DesR/DesK, responsible for cold induction of the des gene coding for the Delta5 acyl-lipid desaturase. Acts as a sensor of the membrane fluidity. Probably activates DesR by phosphorylation
 
 0.847
ydfH
Two-component system, narl family, sensor histidine kinase ydfh; Member of the two-component regulatory system YdfH/YdfI. May activate YdfI by phosphorylation
 
 0.831
Your Current Organism:
Bacillus subtilis
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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