node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
degU | liaS | BSU35490 | BSU33090 | Two-component response regulator; Member of the two-component regulatory system DegS/DegU, which plays an important role in the transition growth phase. Involved in the control of expression of different cellular functions, including production of degradative enzymes such as the neutral and alkaline proteases, flagellum formation, biofilm formation, and competence for DNA uptake. Positively or negatively regulates expression of many different genes. The phosphorylated form is required for synthesis of degradative enzymes, flagellum formation and biofilm formation. The unphosphorylated [...] | Two-component sensor histidine kinase [YvqC] sensing cell wall stress; Member of the two-component regulatory system LiaS/LiaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also involved in response to cationic antimicrobial peptides and secretion stress. Activates probably LiaR by phosphorylation. | 0.830 |
desR | liaS | BSU19200 | BSU33090 | Two-component response regulator [DesK]; Member of the two-component regulatory system DesR/DesK, responsible for cold induction of the des gene coding for the Delta5 acyl-lipid desaturase. | Two-component sensor histidine kinase [YvqC] sensing cell wall stress; Member of the two-component regulatory system LiaS/LiaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also involved in response to cationic antimicrobial peptides and secretion stress. Activates probably LiaR by phosphorylation. | 0.873 |
liaF | liaG | BSU33100 | BSU33110 | Integral inner membrane protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type m: membrane component. | Conserved hypothetical protein (response to antibiotic stress); Evidence 1a: Function experimentally demonstrated in the studied strain; PubMedId: 15273097, 16816187. | 0.999 |
liaF | liaH | BSU33100 | BSU33120 | Integral inner membrane protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type m: membrane component. | Modulator of liaIHGFSR (yvqIHGFEC) operon expression; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor. | 0.994 |
liaF | liaI | BSU33100 | BSU33130 | Integral inner membrane protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type m: membrane component. | Permease; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type t: transporter. | 0.985 |
liaF | liaR | BSU33100 | BSU33080 | Integral inner membrane protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type m: membrane component. | Two-component response regulator [YvqE] responding to cell wall stress; Member of the two-component regulatory system LiaS/LiaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also involved in response to cationic antimicrobial peptides and secretion stress. LiaR regulates the transcription of the liaIHGFSR operon. | 0.999 |
liaF | liaS | BSU33100 | BSU33090 | Integral inner membrane protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type m: membrane component. | Two-component sensor histidine kinase [YvqC] sensing cell wall stress; Member of the two-component regulatory system LiaS/LiaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also involved in response to cationic antimicrobial peptides and secretion stress. Activates probably LiaR by phosphorylation. | 0.999 |
liaG | liaF | BSU33110 | BSU33100 | Conserved hypothetical protein (response to antibiotic stress); Evidence 1a: Function experimentally demonstrated in the studied strain; PubMedId: 15273097, 16816187. | Integral inner membrane protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type m: membrane component. | 0.999 |
liaG | liaH | BSU33110 | BSU33120 | Conserved hypothetical protein (response to antibiotic stress); Evidence 1a: Function experimentally demonstrated in the studied strain; PubMedId: 15273097, 16816187. | Modulator of liaIHGFSR (yvqIHGFEC) operon expression; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor. | 0.995 |
liaG | liaI | BSU33110 | BSU33130 | Conserved hypothetical protein (response to antibiotic stress); Evidence 1a: Function experimentally demonstrated in the studied strain; PubMedId: 15273097, 16816187. | Permease; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type t: transporter. | 0.990 |
liaG | liaR | BSU33110 | BSU33080 | Conserved hypothetical protein (response to antibiotic stress); Evidence 1a: Function experimentally demonstrated in the studied strain; PubMedId: 15273097, 16816187. | Two-component response regulator [YvqE] responding to cell wall stress; Member of the two-component regulatory system LiaS/LiaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also involved in response to cationic antimicrobial peptides and secretion stress. LiaR regulates the transcription of the liaIHGFSR operon. | 0.992 |
liaG | liaS | BSU33110 | BSU33090 | Conserved hypothetical protein (response to antibiotic stress); Evidence 1a: Function experimentally demonstrated in the studied strain; PubMedId: 15273097, 16816187. | Two-component sensor histidine kinase [YvqC] sensing cell wall stress; Member of the two-component regulatory system LiaS/LiaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also involved in response to cationic antimicrobial peptides and secretion stress. Activates probably LiaR by phosphorylation. | 0.997 |
liaH | liaF | BSU33120 | BSU33100 | Modulator of liaIHGFSR (yvqIHGFEC) operon expression; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor. | Integral inner membrane protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type m: membrane component. | 0.994 |
liaH | liaG | BSU33120 | BSU33110 | Modulator of liaIHGFSR (yvqIHGFEC) operon expression; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor. | Conserved hypothetical protein (response to antibiotic stress); Evidence 1a: Function experimentally demonstrated in the studied strain; PubMedId: 15273097, 16816187. | 0.995 |
liaH | liaI | BSU33120 | BSU33130 | Modulator of liaIHGFSR (yvqIHGFEC) operon expression; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor. | Permease; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type t: transporter. | 0.999 |
liaH | liaR | BSU33120 | BSU33080 | Modulator of liaIHGFSR (yvqIHGFEC) operon expression; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor. | Two-component response regulator [YvqE] responding to cell wall stress; Member of the two-component regulatory system LiaS/LiaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also involved in response to cationic antimicrobial peptides and secretion stress. LiaR regulates the transcription of the liaIHGFSR operon. | 0.981 |
liaH | liaS | BSU33120 | BSU33090 | Modulator of liaIHGFSR (yvqIHGFEC) operon expression; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor. | Two-component sensor histidine kinase [YvqC] sensing cell wall stress; Member of the two-component regulatory system LiaS/LiaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also involved in response to cationic antimicrobial peptides and secretion stress. Activates probably LiaR by phosphorylation. | 0.976 |
liaI | liaF | BSU33130 | BSU33100 | Permease; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type t: transporter. | Integral inner membrane protein; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type m: membrane component. | 0.985 |
liaI | liaG | BSU33130 | BSU33110 | Permease; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type t: transporter. | Conserved hypothetical protein (response to antibiotic stress); Evidence 1a: Function experimentally demonstrated in the studied strain; PubMedId: 15273097, 16816187. | 0.990 |
liaI | liaH | BSU33130 | BSU33120 | Permease; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type t: transporter. | Modulator of liaIHGFSR (yvqIHGFEC) operon expression; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor. | 0.999 |