Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
pduOPutative ATP:cob(I)alamin adenosyltransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e: enzyme. (193 aa)    
Predicted Functional Partners:
yvrC
Putative lipoprotein binding vitamin B12; Probably part of an ABC transporter complex.
  
  
 0.924
yvrA
Putative vitamin B12 transport system, ATPase component; Probably part of an ABC transporter complex. Probably responsible for energy coupling to the transport system (By similarity).
  
    0.892
yvrB
Putative vitamin B12 permease; Probably part of an ABC transporter complex. Probably responsible for the translocation of the substrate across the membrane (By similarity).
  
  
 0.817
yqjC
Putative methylmalonyl-CoA epimerase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the methylmalonyl-CoA epimerase family.
  
     0.546
nasF
uroporphyrin-III C-methyltransferase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the precorrin methyltransferase family.
 
   
 0.509
yphB
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function.
      
 0.484
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity.
 
   
 0.482
yvqJ
Putative efflux protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter.
       0.458
yrvC
Putative potassium transport accessory component; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.
      
 0.457
nrdEB
SPbeta phage ribonucleoside reductase alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity); Belongs to the ribonucleoside diphosphate reductase large chain family.
     
 0.444
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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