node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
arsR | copA | BSU25810 | BSU33500 | Transcriptional regulator (ArsR family); Transcriptional repressor for the ars operon. | Copper transporter ATPase; Involved in copper export. | 0.493 |
arsR | copB | BSU25810 | BSU33490 | Transcriptional regulator (ArsR family); Transcriptional repressor for the ars operon. | copper(I)-transporting ATPase; Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell. Does not seem to transport copper. | 0.564 |
arsR | copZ | BSU25810 | BSU33510 | Transcriptional regulator (ArsR family); Transcriptional repressor for the ars operon. | Copper insertion chaperone and transporter component; Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-transporting ATPase CopA. Functions in E.coli to transfer Cu(+) to CopA missing its first metal-binding domain. | 0.567 |
arsR | csoR | BSU25810 | BSU33520 | Transcriptional regulator (ArsR family); Transcriptional repressor for the ars operon. | Repressor of copper utilisation proteins; Copper-sensitive repressor that has a key role in copper homeostasis. Negatively regulates expression of the copZA operon and of ycnJ. In the absence of copper ions, binds with high affinity to the copZA promoter and represses the transcription. In the presence of copper ions, CsoR binds Cu(1+), which significantly decreases its DNA binding affinity and leads to the transcription of the genes. | 0.923 |
arsR | czrA | BSU25810 | BSU19120 | Transcriptional regulator (ArsR family); Transcriptional repressor for the ars operon. | Transcriptional regulator (multiple metal-sensing ArsR-SmtB transcriptional repressors family); Metal-responsive transcriptional regulator that represses transcription of cadA and the czcD-trkA operon by binding specifically to their promoter. Binding of zinc causes the repressor to dissociate from the DNA. | 0.992 |
arsR | ycnJ | BSU25810 | BSU03950 | Transcriptional regulator (ArsR family); Transcriptional repressor for the ars operon. | Putative copper import protein; Involved in uptake of extracellular oxidized copper under copper-limiting conditions; In the N-terminal section; belongs to the CopC family. | 0.572 |
bdbC | bdbD | BSU33470 | BSU33480 | Thiol-disulfide oxidoreductase; Required for the stabilization, possibly via formation of a disulfide bond, of the obligatory competence protein ComGC. Not normally required for production of the secreted lantibiotic sublancin 168, although it can partially substitute for BdbB when the latter is absent. It may also be required for the stability of other secreted proteins. Not required for sporulation; Belongs to the DsbB family. BdbC subfamily. | Thiol-disulfide oxidoreductase; Required for the stabilization, possibly via formation of a disulfide bond, of the obligatory competence protein ComGC. May be required for the stability of secreted proteins with disulfide bonds. Not required for sporulation. | 0.999 |
bdbC | copA | BSU33470 | BSU33500 | Thiol-disulfide oxidoreductase; Required for the stabilization, possibly via formation of a disulfide bond, of the obligatory competence protein ComGC. Not normally required for production of the secreted lantibiotic sublancin 168, although it can partially substitute for BdbB when the latter is absent. It may also be required for the stability of other secreted proteins. Not required for sporulation; Belongs to the DsbB family. BdbC subfamily. | Copper transporter ATPase; Involved in copper export. | 0.527 |
bdbC | copB | BSU33470 | BSU33490 | Thiol-disulfide oxidoreductase; Required for the stabilization, possibly via formation of a disulfide bond, of the obligatory competence protein ComGC. Not normally required for production of the secreted lantibiotic sublancin 168, although it can partially substitute for BdbB when the latter is absent. It may also be required for the stability of other secreted proteins. Not required for sporulation; Belongs to the DsbB family. BdbC subfamily. | copper(I)-transporting ATPase; Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell. Does not seem to transport copper. | 0.518 |
bdbD | bdbC | BSU33480 | BSU33470 | Thiol-disulfide oxidoreductase; Required for the stabilization, possibly via formation of a disulfide bond, of the obligatory competence protein ComGC. May be required for the stability of secreted proteins with disulfide bonds. Not required for sporulation. | Thiol-disulfide oxidoreductase; Required for the stabilization, possibly via formation of a disulfide bond, of the obligatory competence protein ComGC. Not normally required for production of the secreted lantibiotic sublancin 168, although it can partially substitute for BdbB when the latter is absent. It may also be required for the stability of other secreted proteins. Not required for sporulation; Belongs to the DsbB family. BdbC subfamily. | 0.999 |
bdbD | copA | BSU33480 | BSU33500 | Thiol-disulfide oxidoreductase; Required for the stabilization, possibly via formation of a disulfide bond, of the obligatory competence protein ComGC. May be required for the stability of secreted proteins with disulfide bonds. Not required for sporulation. | Copper transporter ATPase; Involved in copper export. | 0.590 |
bdbD | copB | BSU33480 | BSU33490 | Thiol-disulfide oxidoreductase; Required for the stabilization, possibly via formation of a disulfide bond, of the obligatory competence protein ComGC. May be required for the stability of secreted proteins with disulfide bonds. Not required for sporulation. | copper(I)-transporting ATPase; Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell. Does not seem to transport copper. | 0.561 |
copA | arsR | BSU33500 | BSU25810 | Copper transporter ATPase; Involved in copper export. | Transcriptional regulator (ArsR family); Transcriptional repressor for the ars operon. | 0.493 |
copA | bdbC | BSU33500 | BSU33470 | Copper transporter ATPase; Involved in copper export. | Thiol-disulfide oxidoreductase; Required for the stabilization, possibly via formation of a disulfide bond, of the obligatory competence protein ComGC. Not normally required for production of the secreted lantibiotic sublancin 168, although it can partially substitute for BdbB when the latter is absent. It may also be required for the stability of other secreted proteins. Not required for sporulation; Belongs to the DsbB family. BdbC subfamily. | 0.527 |
copA | bdbD | BSU33500 | BSU33480 | Copper transporter ATPase; Involved in copper export. | Thiol-disulfide oxidoreductase; Required for the stabilization, possibly via formation of a disulfide bond, of the obligatory competence protein ComGC. May be required for the stability of secreted proteins with disulfide bonds. Not required for sporulation. | 0.590 |
copA | copB | BSU33500 | BSU33490 | Copper transporter ATPase; Involved in copper export. | copper(I)-transporting ATPase; Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell. Does not seem to transport copper. | 0.822 |
copA | copZ | BSU33500 | BSU33510 | Copper transporter ATPase; Involved in copper export. | Copper insertion chaperone and transporter component; Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-transporting ATPase CopA. Functions in E.coli to transfer Cu(+) to CopA missing its first metal-binding domain. | 0.997 |
copA | csoR | BSU33500 | BSU33520 | Copper transporter ATPase; Involved in copper export. | Repressor of copper utilisation proteins; Copper-sensitive repressor that has a key role in copper homeostasis. Negatively regulates expression of the copZA operon and of ycnJ. In the absence of copper ions, binds with high affinity to the copZA promoter and represses the transcription. In the presence of copper ions, CsoR binds Cu(1+), which significantly decreases its DNA binding affinity and leads to the transcription of the genes. | 0.846 |
copA | czcD | BSU33500 | BSU26650 | Copper transporter ATPase; Involved in copper export. | Potassium/proton-divalent cation antiporter; Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions. | 0.502 |
copA | czrA | BSU33500 | BSU19120 | Copper transporter ATPase; Involved in copper export. | Transcriptional regulator (multiple metal-sensing ArsR-SmtB transcriptional repressors family); Metal-responsive transcriptional regulator that represses transcription of cadA and the czcD-trkA operon by binding specifically to their promoter. Binding of zinc causes the repressor to dissociate from the DNA. | 0.524 |