node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
bdbD | copA | BSU33480 | BSU33500 | Thiol-disulfide oxidoreductase; Required for the stabilization, possibly via formation of a disulfide bond, of the obligatory competence protein ComGC. May be required for the stability of secreted proteins with disulfide bonds. Not required for sporulation. | Copper transporter ATPase; Involved in copper export. | 0.590 |
bdbD | copB | BSU33480 | BSU33490 | Thiol-disulfide oxidoreductase; Required for the stabilization, possibly via formation of a disulfide bond, of the obligatory competence protein ComGC. May be required for the stability of secreted proteins with disulfide bonds. Not required for sporulation. | copper(I)-transporting ATPase; Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell. Does not seem to transport copper. | 0.561 |
copA | bdbD | BSU33500 | BSU33480 | Copper transporter ATPase; Involved in copper export. | Thiol-disulfide oxidoreductase; Required for the stabilization, possibly via formation of a disulfide bond, of the obligatory competence protein ComGC. May be required for the stability of secreted proteins with disulfide bonds. Not required for sporulation. | 0.590 |
copA | copB | BSU33500 | BSU33490 | Copper transporter ATPase; Involved in copper export. | copper(I)-transporting ATPase; Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell. Does not seem to transport copper. | 0.822 |
copA | copZ | BSU33500 | BSU33510 | Copper transporter ATPase; Involved in copper export. | Copper insertion chaperone and transporter component; Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-transporting ATPase CopA. Functions in E.coli to transfer Cu(+) to CopA missing its first metal-binding domain. | 0.997 |
copA | cotA | BSU33500 | BSU06300 | Copper transporter ATPase; Involved in copper export. | Outer spore coat copper-dependent laccase; Involved in brown pigmentation during sporogenesis. | 0.668 |
copA | csoR | BSU33500 | BSU33520 | Copper transporter ATPase; Involved in copper export. | Repressor of copper utilisation proteins; Copper-sensitive repressor that has a key role in copper homeostasis. Negatively regulates expression of the copZA operon and of ycnJ. In the absence of copper ions, binds with high affinity to the copZA promoter and represses the transcription. In the presence of copper ions, CsoR binds Cu(1+), which significantly decreases its DNA binding affinity and leads to the transcription of the genes. | 0.846 |
copA | sodC | BSU33500 | BSU19400 | Copper transporter ATPase; Involved in copper export. | Superoxide dismutase (exported lipoprotein); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type lp: lipoprotein. | 0.980 |
copA | yrkD | BSU33500 | BSU26550 | Copper transporter ATPase; Involved in copper export. | Putative transcriptional regulator; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. | 0.548 |
copA | yrkF | BSU33500 | BSU26530 | Copper transporter ATPase; Involved in copper export. | Putative rhodanese-related sulfur transferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the sulfur carrier protein TusA family. | 0.580 |
copA | znuC | BSU33500 | BSU02860 | Copper transporter ATPase; Involved in copper export. | Zn(II) transporter (ATP-binding protein); Part of the high-affinity ABC transporter complex ZnuABC involved in zinc import (Probable). Responsible for energy coupling to the transport system (By similarity). ZnuABC-mediated zinc transport is required for comF expression and competence development. | 0.698 |
copA | zosA | BSU33500 | BSU13850 | Copper transporter ATPase; Involved in copper export. | Zn transporter; Couples the hydrolysis of ATP with the transport of zinc into the cell. Plays an important role in protecting cells against oxidative stress. ZosA-mediated zinc transport is required for post- transcriptional control of comK and competence development. | 0.635 |
copB | bdbD | BSU33490 | BSU33480 | copper(I)-transporting ATPase; Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell. Does not seem to transport copper. | Thiol-disulfide oxidoreductase; Required for the stabilization, possibly via formation of a disulfide bond, of the obligatory competence protein ComGC. May be required for the stability of secreted proteins with disulfide bonds. Not required for sporulation. | 0.561 |
copB | copA | BSU33490 | BSU33500 | copper(I)-transporting ATPase; Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell. Does not seem to transport copper. | Copper transporter ATPase; Involved in copper export. | 0.822 |
copB | copZ | BSU33490 | BSU33510 | copper(I)-transporting ATPase; Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell. Does not seem to transport copper. | Copper insertion chaperone and transporter component; Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-transporting ATPase CopA. Functions in E.coli to transfer Cu(+) to CopA missing its first metal-binding domain. | 0.983 |
copB | csoR | BSU33490 | BSU33520 | copper(I)-transporting ATPase; Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell. Does not seem to transport copper. | Repressor of copper utilisation proteins; Copper-sensitive repressor that has a key role in copper homeostasis. Negatively regulates expression of the copZA operon and of ycnJ. In the absence of copper ions, binds with high affinity to the copZA promoter and represses the transcription. In the presence of copper ions, CsoR binds Cu(1+), which significantly decreases its DNA binding affinity and leads to the transcription of the genes. | 0.857 |
copZ | copA | BSU33510 | BSU33500 | Copper insertion chaperone and transporter component; Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-transporting ATPase CopA. Functions in E.coli to transfer Cu(+) to CopA missing its first metal-binding domain. | Copper transporter ATPase; Involved in copper export. | 0.997 |
copZ | copB | BSU33510 | BSU33490 | Copper insertion chaperone and transporter component; Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-transporting ATPase CopA. Functions in E.coli to transfer Cu(+) to CopA missing its first metal-binding domain. | copper(I)-transporting ATPase; Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell. Does not seem to transport copper. | 0.983 |
copZ | csoR | BSU33510 | BSU33520 | Copper insertion chaperone and transporter component; Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-transporting ATPase CopA. Functions in E.coli to transfer Cu(+) to CopA missing its first metal-binding domain. | Repressor of copper utilisation proteins; Copper-sensitive repressor that has a key role in copper homeostasis. Negatively regulates expression of the copZA operon and of ycnJ. In the absence of copper ions, binds with high affinity to the copZA promoter and represses the transcription. In the presence of copper ions, CsoR binds Cu(1+), which significantly decreases its DNA binding affinity and leads to the transcription of the genes. | 0.997 |
copZ | sodC | BSU33510 | BSU19400 | Copper insertion chaperone and transporter component; Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-transporting ATPase CopA. Functions in E.coli to transfer Cu(+) to CopA missing its first metal-binding domain. | Superoxide dismutase (exported lipoprotein); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type lp: lipoprotein. | 0.933 |