node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
sdpI | sdpR | BSU33780 | BSU33790 | Integral membrane regulator of autophagy; Immunity protein that provides protection for the cell against the toxic effects of SDP, its own SdpC-derived killing factor, and that functions as a receptor/signal transduction protein as well. Once SDP accumulates in the extracellular milieu, SdpI binds to SDP, causing sequestration of SdpR at the bacterial membrane. | Transcriptional regulator (ArsR family); Represses the transcription of the sdpIR operon and of several other operons that probably contribute to delaying commitment to sporulation. | 0.999 |
sdpI | skfA | BSU33780 | BSU01910 | Integral membrane regulator of autophagy; Immunity protein that provides protection for the cell against the toxic effects of SDP, its own SdpC-derived killing factor, and that functions as a receptor/signal transduction protein as well. Once SDP accumulates in the extracellular milieu, SdpI binds to SDP, causing sequestration of SdpR at the bacterial membrane. | Sporulation killing factor A; Produces a 26-residue extracellular sporulation filling factor (SKF) that induces the lysis of other B.subtilis cells that have not entered the sporulation pathway, providing a source of nutrients to support sporulation, and at the same time delaying commitment to the energetically expensive and irreversible onset of sporulation. Can also inhibit growth of other bacteria at high concentrations. Addition of SKF to solid cultures induces killing, but it is much less effective than SDP (AC O34344). Has a role in protecting the secreted lipase LipA against pro [...] | 0.685 |
sdpI | skfF | BSU33780 | BSU01960 | Integral membrane regulator of autophagy; Immunity protein that provides protection for the cell against the toxic effects of SDP, its own SdpC-derived killing factor, and that functions as a receptor/signal transduction protein as well. Once SDP accumulates in the extracellular milieu, SdpI binds to SDP, causing sequestration of SdpR at the bacterial membrane. | Sporulation killing factor biosynthesis and export; Probably part of the ABC transporter SkfEF involved in the export of the bacteriocin SKF. Probably responsible for the translocation of bacteriocin SkfA across the membrane. | 0.563 |
sdpI | spbC | BSU33780 | BSU33770 | Integral membrane regulator of autophagy; Immunity protein that provides protection for the cell against the toxic effects of SDP, its own SdpC-derived killing factor, and that functions as a receptor/signal transduction protein as well. Once SDP accumulates in the extracellular milieu, SdpI binds to SDP, causing sequestration of SdpR at the bacterial membrane. | Killing factor SdpC; Produces a 42-residue extracellular sporulation delaying protein (SDP) that collapses the proton motive force (probably both the membrane potential and pH gradient) across the cell membrane, which leads to autolysis; may form a proton channel. Induces the lysis of other B.subtilis cells that have not entered the sporulation pathway, inducing cannibalism to provide a source of nutrients to support sporulation, and at the same time delaying commitment to the energetically expensive and irreversible onset of sporulation. Addition of SDP to liquid cultures halts growth [...] | 0.917 |
sdpI | ydeB | BSU33780 | BSU05130 | Integral membrane regulator of autophagy; Immunity protein that provides protection for the cell against the toxic effects of SDP, its own SdpC-derived killing factor, and that functions as a receptor/signal transduction protein as well. Once SDP accumulates in the extracellular milieu, SdpI binds to SDP, causing sequestration of SdpR at the bacterial membrane. | Putative transcriptional regulator; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator; Belongs to the CarD family. | 0.576 |
sdpI | yitQ | BSU33780 | BSU11080 | Integral membrane regulator of autophagy; Immunity protein that provides protection for the cell against the toxic effects of SDP, its own SdpC-derived killing factor, and that functions as a receptor/signal transduction protein as well. Once SDP accumulates in the extracellular milieu, SdpI binds to SDP, causing sequestration of SdpR at the bacterial membrane. | Hypothetical protein; Evidence 5: No homology to any previously reported sequences. | 0.487 |
sdpI | yizB | BSU33780 | BSU11079 | Integral membrane regulator of autophagy; Immunity protein that provides protection for the cell against the toxic effects of SDP, its own SdpC-derived killing factor, and that functions as a receptor/signal transduction protein as well. Once SDP accumulates in the extracellular milieu, SdpI binds to SDP, causing sequestration of SdpR at the bacterial membrane. | Putative DNA/RNA binding protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf: putative factor. | 0.790 |
sdpI | ylbP | BSU33780 | BSU15100 | Integral membrane regulator of autophagy; Immunity protein that provides protection for the cell against the toxic effects of SDP, its own SdpC-derived killing factor, and that functions as a receptor/signal transduction protein as well. Once SDP accumulates in the extracellular milieu, SdpI binds to SDP, causing sequestration of SdpR at the bacterial membrane. | Putative acetyltransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. | 0.487 |
sdpR | sdpI | BSU33790 | BSU33780 | Transcriptional regulator (ArsR family); Represses the transcription of the sdpIR operon and of several other operons that probably contribute to delaying commitment to sporulation. | Integral membrane regulator of autophagy; Immunity protein that provides protection for the cell against the toxic effects of SDP, its own SdpC-derived killing factor, and that functions as a receptor/signal transduction protein as well. Once SDP accumulates in the extracellular milieu, SdpI binds to SDP, causing sequestration of SdpR at the bacterial membrane. | 0.999 |
sdpR | skfA | BSU33790 | BSU01910 | Transcriptional regulator (ArsR family); Represses the transcription of the sdpIR operon and of several other operons that probably contribute to delaying commitment to sporulation. | Sporulation killing factor A; Produces a 26-residue extracellular sporulation filling factor (SKF) that induces the lysis of other B.subtilis cells that have not entered the sporulation pathway, providing a source of nutrients to support sporulation, and at the same time delaying commitment to the energetically expensive and irreversible onset of sporulation. Can also inhibit growth of other bacteria at high concentrations. Addition of SKF to solid cultures induces killing, but it is much less effective than SDP (AC O34344). Has a role in protecting the secreted lipase LipA against pro [...] | 0.690 |
sdpR | skfB | BSU33790 | BSU01920 | Transcriptional regulator (ArsR family); Represses the transcription of the sdpIR operon and of several other operons that probably contribute to delaying commitment to sporulation. | Synthesis of sporulation killing factor A; Catalyzes the formation of the thioether bond required for production of the sporulation killing factor (SKF) from SkfA. Forms the cysteine-methionine thioether bond found in SKF; the acceptor amino acid can be hydrophobic, aromatic or a small hydrophilic amino acid but not a larger hydrophilic amino acid, i.e. Met=Ala, Phe, Leu, Tyr>Asn, Ser>>Gln, Glu, Lys. The relative position of Cys and Met in the substrate cannot be inverted, in vitro the thioether bond cannot be made in the absence of the SkfA propeptide, suggesting this is the first rea [...] | 0.685 |
sdpR | skfF | BSU33790 | BSU01960 | Transcriptional regulator (ArsR family); Represses the transcription of the sdpIR operon and of several other operons that probably contribute to delaying commitment to sporulation. | Sporulation killing factor biosynthesis and export; Probably part of the ABC transporter SkfEF involved in the export of the bacteriocin SKF. Probably responsible for the translocation of bacteriocin SkfA across the membrane. | 0.580 |
sdpR | skfH | BSU33790 | BSU01980 | Transcriptional regulator (ArsR family); Represses the transcription of the sdpIR operon and of several other operons that probably contribute to delaying commitment to sporulation. | Sibling killing effect; Required for production of the bacteriocin SkfA. | 0.685 |
sdpR | spbC | BSU33790 | BSU33770 | Transcriptional regulator (ArsR family); Represses the transcription of the sdpIR operon and of several other operons that probably contribute to delaying commitment to sporulation. | Killing factor SdpC; Produces a 42-residue extracellular sporulation delaying protein (SDP) that collapses the proton motive force (probably both the membrane potential and pH gradient) across the cell membrane, which leads to autolysis; may form a proton channel. Induces the lysis of other B.subtilis cells that have not entered the sporulation pathway, inducing cannibalism to provide a source of nutrients to support sporulation, and at the same time delaying commitment to the energetically expensive and irreversible onset of sporulation. Addition of SDP to liquid cultures halts growth [...] | 0.850 |
sdpR | ydeB | BSU33790 | BSU05130 | Transcriptional regulator (ArsR family); Represses the transcription of the sdpIR operon and of several other operons that probably contribute to delaying commitment to sporulation. | Putative transcriptional regulator; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator; Belongs to the CarD family. | 0.683 |
sdpR | yitQ | BSU33790 | BSU11080 | Transcriptional regulator (ArsR family); Represses the transcription of the sdpIR operon and of several other operons that probably contribute to delaying commitment to sporulation. | Hypothetical protein; Evidence 5: No homology to any previously reported sequences. | 0.568 |
sdpR | yizB | BSU33790 | BSU11079 | Transcriptional regulator (ArsR family); Represses the transcription of the sdpIR operon and of several other operons that probably contribute to delaying commitment to sporulation. | Putative DNA/RNA binding protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf: putative factor. | 0.760 |
sdpR | ylbP | BSU33790 | BSU15100 | Transcriptional regulator (ArsR family); Represses the transcription of the sdpIR operon and of several other operons that probably contribute to delaying commitment to sporulation. | Putative acetyltransferase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. | 0.586 |
skfA | sdpI | BSU01910 | BSU33780 | Sporulation killing factor A; Produces a 26-residue extracellular sporulation filling factor (SKF) that induces the lysis of other B.subtilis cells that have not entered the sporulation pathway, providing a source of nutrients to support sporulation, and at the same time delaying commitment to the energetically expensive and irreversible onset of sporulation. Can also inhibit growth of other bacteria at high concentrations. Addition of SKF to solid cultures induces killing, but it is much less effective than SDP (AC O34344). Has a role in protecting the secreted lipase LipA against pro [...] | Integral membrane regulator of autophagy; Immunity protein that provides protection for the cell against the toxic effects of SDP, its own SdpC-derived killing factor, and that functions as a receptor/signal transduction protein as well. Once SDP accumulates in the extracellular milieu, SdpI binds to SDP, causing sequestration of SdpR at the bacterial membrane. | 0.685 |
skfA | sdpR | BSU01910 | BSU33790 | Sporulation killing factor A; Produces a 26-residue extracellular sporulation filling factor (SKF) that induces the lysis of other B.subtilis cells that have not entered the sporulation pathway, providing a source of nutrients to support sporulation, and at the same time delaying commitment to the energetically expensive and irreversible onset of sporulation. Can also inhibit growth of other bacteria at high concentrations. Addition of SKF to solid cultures induces killing, but it is much less effective than SDP (AC O34344). Has a role in protecting the secreted lipase LipA against pro [...] | Transcriptional regulator (ArsR family); Represses the transcription of the sdpIR operon and of several other operons that probably contribute to delaying commitment to sporulation. | 0.690 |