STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
opuCDGlycine betaine/carnitine/choline/choline sulfate ABC transporter (permease); Involved in a high affinity multicomponent binding-protein- dependent transport system for glycine betaine, carnitine and choline; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (229 aa)    
Predicted Functional Partners:
opuCC
Glycine betaine/carnitine/choline-binding protein OpuCC; Member of a high affinity multicomponent binding-protein- dependent transport system for glycine betaine, carnitine, and choline. Belongs to the OsmX family.
 
 0.999
opuCA
Glycine betaine/carnitine/choline/choline sulfate ABC transporter (ATP-binding protein); Involved in a high affinity multicomponent binding-protein- dependent transport system for glycine betaine, carnitine and choline; probably responsible for energy coupling to the transport system.
 0.999
opuBC
Choline ABC transporter (choline-binding lipoprotein); Member of a high affinity multicomponent binding-protein- dependent transport system for choline.
 
 0.998
opuCB
Glycine betaine/carnitine/choline/choline sulfate ABC transporter (permease); Involved in a high affinity multicomponent binding-protein- dependent transport system for glycine betaine, carnitine and choline; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
 
 
0.995
opuBA
Choline ABC transporter (ATP-binding protein); Involved in a high affinity multicomponent binding-protein- dependent transport system for choline. Probably responsible for energy coupling to the transport system.
 0.994
yvbF
Putative transcriptional regulator; Negatively regulates the transcription of the opuC operon. In the absence of GbsR, is also a negative regulator of the opuB operon. Binds to an inverted repeat in the promoter region of the operons.
  
  
 0.636
yvaV
Putative transcriptional regulator; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr: putative regulator; Belongs to the GbsR family.
     
 0.501
yuaC
Putative transcriptional regulator; Negatively regulates the expression of the gbsAB and opuB operons. Required to control expression of these genes in response to choline availability. Also required to downregulate glycine betaine production once cellular adjustment to high osmolarity has been achieved; Belongs to the GbsR family.
     
 0.498
opuAC
Glycine betaine ABC transporter (glycine betaine-binding lipoprotein); Involved in a multicomponent binding-protein-dependent transport system for glycine betaine.
 
  
 0.493
sdpI
Integral membrane regulator of autophagy; Immunity protein that provides protection for the cell against the toxic effects of SDP, its own SdpC-derived killing factor, and that functions as a receptor/signal transduction protein as well. Once SDP accumulates in the extracellular milieu, SdpI binds to SDP, causing sequestration of SdpR at the bacterial membrane.
       0.435
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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