STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yvfUTwo-component system, narl family, response regulator; Member of the two-component regulatory system YvfT/YvfU (200 aa)    
Predicted Functional Partners:
yvfT
Two-component system, narl family, sensor histidine kinase desk; Member of the two-component regulatory system YvfT/YvfU. Probably activates YvfU by phosphorylation
 
 0.998
yvfS
Putative transport permease YvfS; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter
   
 0.993
yvfR
Putative abc efflux transporter (atp-binding protein); Belongs to the ABC transporter superfamily
  
 0.991
desK
Two-component system, narl family, sensor histidine kinase desk; Member of the two-component regulatory system DesR/DesK, responsible for cold induction of the des gene coding for the Delta5 acyl-lipid desaturase. Acts as a sensor of the membrane fluidity. Probably activates DesR by phosphorylation
 
 0.950
yhcY
Two-component system, narl family, sensor kinase; Member of the two-component regulatory system YhcY/YhcZ. Probably activates YhcZ by phosphorylation
 
 0.867
ykoW
Putative sensor diguanylate cyclase; Probable signaling protein whose physiological role is not yet known
  
  
 0.829
liaS
Two-component sensor histidine kinase [yvqc] sensing cell wall stress; Member of the two-component regulatory system LiaS/LiaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also involved in response to cationic antimicrobial peptides and secretion stress. Activates probably LiaR by phosphorylation
 
 0.818
yfiJ
Two-component sensor histidine kinase [yfik]; Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes . Member of the two-component regulatory system LnrJ/LnrK, which induces expression of the LnrLMN ABC transporter in response to linearmycins and other polyenes . Acts as a specific sensor for linearmycin, either directly through binding or indirectly through membrane perturbation. Probably activates LnrK by phosphorylation . May also promote biofilm formation
 
 0.803
yxjM
Two-component sensor histidine kinase [yxjl]; Probable member of the two-component regulatory system YxjM/YxjL. May activate YxjL by phosphorylation
 
 0.803
nprB
Extracellular neutral protease b; Protease able to cleave casein in vitro
 
 
  
 0.794
Your Current Organism:
Bacillus subtilis
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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