STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yvfIPutative transcriptional regulator (GntR family); Negatively regulates the transcription of the lutABC operon, which is required for L-lactate utilization. LutR activity is regulated by lactate, since presence of L-lactate, that probably binds to LutR, leads to derepression of the operon. Also appears to be essential for bacilysin biosynthesis. (219 aa)    
Predicted Functional Partners:
yvfH
Putative lactate permease; Is the principal permease for the uptake of L-lactate in B.subtilis.
 
  
 0.920
lutC
Component of an iron-sulfur oxidase; Is essential for L-lactate degradation and allows cells to grow with lactate as the sole carbon source. May also allow cells to utilize an alternative carbon source during biofilm formation, since it contributes to the formation of architecturally complex communities when lactate is present.
 
  
 0.789
lutB
Component of an iron-sulfur oxidase; Is essential for L-lactate degradation and allows cells to grow with lactate as the sole carbon source. Has probably a role as an electron transporter during oxidation of L-lactate. May also allow cells to utilize an alternative carbon source during biofilm formation, since it contributes to the formation of architecturally complex communities when lactate is present.
 
   
 0.777
gntR
Transcriptional regulator (GntR family); Transcriptional repressor of the gluconate operon (gntRKPZ), which encodes the proteins for gluconate utilization. Represses mRNA synthesis by binding to the gnt operator; the binding is suppressed by gluconate or glucono-delta-lactone.
 
  
 0.757
ganR
Transcriptional regulator (LacI family); Negatively regulates expression of ganA.
 
 
 0.729
lutA
Iron-sulfur oxidase component; Is essential for L-lactate degradation and allows cells to grow with lactate as the sole carbon source. May also allow cells to utilize an alternative carbon source during biofilm formation, since it contributes to the formation of architecturally complex communities when lactate is present.
 
  
 0.677
ybgA
Putative transcriptional regulator (GntR family); Transcriptional repressor of genes involved in glucosamine transport and utilization. Represses the expression of the gamAP operon by binding to the gamA-gamR intergenic region.
  
    0.611
frlR
FrlR transcriptional regulator (GntR family); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type r: regulator.
  
    0.580
nagR
Transcriptional regulator (GntR family); Main transcriptional repressor of genes involved in N- acetylglucosamine (GlcNAc) transport and utilization. Represses the expression of the nagAB and nagP operons by binding directly within their upstream regions. Binds to the DNA consensus sequence 5'-ATTGGTATAGACAACT-3'. Also acts as a weak repressor of mapB expression.
  
    0.575
gmuR
Transcriptional regulator (GntR family); Transcriptional repressor of the gmuBACDREFG operon which is involved in the uptake and degradation of glucomannan.
  
    0.550
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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