STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
epsAModulator of protein tyrosine kinase EpsB; Evidence 2b: Function of strongly homologous gene; regulator. (234 aa)    
Predicted Functional Partners:
epsB
Protein tyrosine kinase; Evidence 2b: Function of strongly homologous gene; enzyme; Belongs to the CpsD/CapB family.
 
 0.999
sipW
Type I signal peptidase; Required for the cleavage of the signal sequence of TasA and TapA, which are involved in biofilm formation. Belongs to the peptidase S26B family.
   
  
 0.994
tapA
Lipoprotein for biofilm formation; Required for biofilm formation. Required for the proper anchoring and polymerization of TasA amyloid fibers at the cell surface. Is also a minor component of TasA fibers.
   
  
 0.994
epsO
Putative pyruvyl transferase; May be involved in the production of the exopolysaccharide (EPS) component of the extracellular matrix during biofilm formation. EPS is responsible for the adhesion of chains of cells into bundles; Belongs to the polysaccharide pyruvyl transferase family.
 
  
 0.987
epsE
Bifunctional flagellar clutch and glycosyltransferase; May be involved in the production of the exopolysaccharide (EPS) component of the extracellular matrix during biofilm formation. EPS is responsible for the adhesion of chains of cells into bundles. Required for biofilm maintenance; Belongs to the glycosyltransferase 2 family.
  
  
 0.982
ptkA
Protein tyrosine kinase; May be involved in the regulation of capsular polysaccharide biosynthesis. Autophosphorylates in vitro. Phosphorylates and activates in vitro two UDP-glucose dehydrogenases, YwqF and TuaD, as well as the DNA-binding proteins Ssb and SsbB; Belongs to the CpsD/CapB family.
  
 0.978
epsC
Putative UDP-sugar epimerase; Involved in biofilm formation; Belongs to the polysaccharide synthase family.
 
  
 0.977
slrR
Transcriptional regulator of autolysin genes; Represses sigma(D)-dependent flagellar genes and activate the eps and yqxM operons. Repressor activity is regulated by SlrA. Controls the initiation of biofilm formation.
  
  
 0.977
sinR
Master regulator of biofilm formation; Negative as well as positive regulator of alternate developmental processes that are induced at the end of vegetative growth in response to nutrient depletion. Binds to the alkaline protease (aprE) gene at two sites. Also acts as a repressor of the key sporulation gene spo0A. Negatively regulates transcription of the eps operon, which is responsible for the biosynthesis of an exopolysaccharide involved in biofilm formation; therefore it could govern the transition between a state in which bacteria swim or swarm and a state in which bacteria assemb [...]
     
 0.974
epsH
Putative glycosyltransferase involved in biofilm formation; May be involved in the production of the exopolysaccharide (EPS) component of the extracellular matrix during biofilm formation. EPS is responsible for the adhesion of chains of cells into bundles. Required for biofilm maintenance; Belongs to the glycosyltransferase 2 family.
  
  
 0.974
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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