STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
comFBConserved hypothetical protein; Evidence 1a: Function experimentally demonstrated in the studied strain; PubMedId: 16009133, 8045879, 8412657. (98 aa)    
Predicted Functional Partners:
comFC
Putative component of the DNA transport apparatus; Involved in transformation (competence for DNA uptake).
  
  
 0.999
comFA
Helicase competence protein; Involved in transformation (competence for DNA uptake). Required for DNA uptake but not for binding. May provide the driving force for transport of DNA through an aqueous channel. Belongs to the helicase family.
  
  
 0.965
nucA
Endonuclease; By degrading DNA that enters the cell, plays a role in the competence of cells to be transformed. Degrades both double-stranded, linear and covalently closed circular DNA.
   
  
 0.864
comGB
Membrane platform component of the DNA transport machinery; Required for transformation and DNA binding. Belongs to the GSP F family.
  
  
 0.853
yvyF
Putative regulator of flagella formation; May be involved in the assembly, structure, or function of the flagellum. May polymerize to form a filamentous structure that is part of the flagellum.
  
  
 0.822
comGE
Component of the DNA transport platform; Required for transformation and DNA binding.
   
  
 0.798
comGF
Component of the DNA transport platform; Required for transformation and DNA binding.
   
  
 0.765
comGA
Membrane associated ATPase for DNA competence; Required for uptake of DNA by competent cells.
  
  
 0.758
ssbB
Single-strand DNA-binding protein; Not essential for replication of the chromosome, but is required for optimal competence. Binds ssDNA, binding is facilitated by DprA, acts as an accessory factor for homologous DNA strand exchange.
   
  
 0.752
comGD
Membrane component of the DNA transport platform; Required for transformation and DNA binding.
  
  
 0.727
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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