node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
capA | capB | BSU35880 | BSU35900 | Capsular polyglutamate synthetase; Seems to be required for maximum PGA (gamma-polyglutamic acid) production; Belongs to the CapA family. | Capsular polyglutamate synthetase (ATP-dependent amide ligase); Catalyzes the biosynthesis of PGA (gamma-polyglutamic acid) from L-glutamate. Both the 44-kDa and the 33-kDa forms are required for PGA synthesis. | 0.995 |
capA | capC | BSU35880 | BSU35890 | Capsular polyglutamate synthetase; Seems to be required for maximum PGA (gamma-polyglutamic acid) production; Belongs to the CapA family. | Capsular polyglutamate amide ligase/translocase subunit; Required for PGA (gamma-polyglutamic acid) biosynthesis. | 0.998 |
capA | capE | BSU35880 | BSU35870 | Capsular polyglutamate synthetase; Seems to be required for maximum PGA (gamma-polyglutamic acid) production; Belongs to the CapA family. | Factor required for polyglutamate synthesis; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor. | 0.973 |
capA | pgdS | BSU35880 | BSU35860 | Capsular polyglutamate synthetase; Seems to be required for maximum PGA (gamma-polyglutamic acid) production; Belongs to the CapA family. | gamma-DD-glutamyl hydrolase (PGA depolymerase); Cleaves, in an endo-type manner, the gamma-glutamyl bond between D-glutamate and L-glutamate of poly-gamma-glutamate (PGA). | 0.882 |
capB | capA | BSU35900 | BSU35880 | Capsular polyglutamate synthetase (ATP-dependent amide ligase); Catalyzes the biosynthesis of PGA (gamma-polyglutamic acid) from L-glutamate. Both the 44-kDa and the 33-kDa forms are required for PGA synthesis. | Capsular polyglutamate synthetase; Seems to be required for maximum PGA (gamma-polyglutamic acid) production; Belongs to the CapA family. | 0.995 |
capB | capC | BSU35900 | BSU35890 | Capsular polyglutamate synthetase (ATP-dependent amide ligase); Catalyzes the biosynthesis of PGA (gamma-polyglutamic acid) from L-glutamate. Both the 44-kDa and the 33-kDa forms are required for PGA synthesis. | Capsular polyglutamate amide ligase/translocase subunit; Required for PGA (gamma-polyglutamic acid) biosynthesis. | 0.999 |
capB | capE | BSU35900 | BSU35870 | Capsular polyglutamate synthetase (ATP-dependent amide ligase); Catalyzes the biosynthesis of PGA (gamma-polyglutamic acid) from L-glutamate. Both the 44-kDa and the 33-kDa forms are required for PGA synthesis. | Factor required for polyglutamate synthesis; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor. | 0.995 |
capB | comP | BSU35900 | BSU31690 | Capsular polyglutamate synthetase (ATP-dependent amide ligase); Catalyzes the biosynthesis of PGA (gamma-polyglutamic acid) from L-glutamate. Both the 44-kDa and the 33-kDa forms are required for PGA synthesis. | Two-component sensor histidine kinase; Sensor in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Plays a role in sporulation, at least partly interchangeable with that of SpoIIJ. Probably activates ComA by phosphorylation. | 0.483 |
capB | degQ | BSU35900 | BSU31720 | Capsular polyglutamate synthetase (ATP-dependent amide ligase); Catalyzes the biosynthesis of PGA (gamma-polyglutamic acid) from L-glutamate. Both the 44-kDa and the 33-kDa forms are required for PGA synthesis. | Pleiotropic regulator; Stimulates the phosphotransfer from phospho-DegS to DegU. Affects protease and levansucrose production. | 0.681 |
capB | degS | BSU35900 | BSU35500 | Capsular polyglutamate synthetase (ATP-dependent amide ligase); Catalyzes the biosynthesis of PGA (gamma-polyglutamic acid) from L-glutamate. Both the 44-kDa and the 33-kDa forms are required for PGA synthesis. | Two-component sensor histidine kinase; Member of the two-component regulatory system DegS/DegU, which plays an important role in the transition growth phase. Involved in the control of expression of different cellular functions, including production of degradative enzymes such as the neutral and alkaline proteases, flagellum formation and biofilm formation. Acts as both a protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to DegU, and a protein phosphatase that dephosphorylates phospho-DegU. | 0.680 |
capB | gudB | BSU35900 | BSU22960 | Capsular polyglutamate synthetase (ATP-dependent amide ligase); Catalyzes the biosynthesis of PGA (gamma-polyglutamic acid) from L-glutamate. Both the 44-kDa and the 33-kDa forms are required for PGA synthesis. | Cryptic glutamate dehydrogenase; GudB seems to be intrinsically inactive, however spontaneous mutations removing a 9-bp direct repeat within the wild-type gudB sequence activated the GudB protein and allowed more-efficient utilization of amino acids of the glutamate family. This insertion presumably causes severe destabilization of the fold of the protein, leading to an inactive enzyme that is very quickly degraded. The cryptic GudB serves as a buffer that may compensate for mutations in the rocG gene and that can also be decryptified for the utilization of glutamate as a single carbon [...] | 0.483 |
capB | pgdS | BSU35900 | BSU35860 | Capsular polyglutamate synthetase (ATP-dependent amide ligase); Catalyzes the biosynthesis of PGA (gamma-polyglutamic acid) from L-glutamate. Both the 44-kDa and the 33-kDa forms are required for PGA synthesis. | gamma-DD-glutamyl hydrolase (PGA depolymerase); Cleaves, in an endo-type manner, the gamma-glutamyl bond between D-glutamate and L-glutamate of poly-gamma-glutamate (PGA). | 0.964 |
capB | rocG | BSU35900 | BSU37790 | Capsular polyglutamate synthetase (ATP-dependent amide ligase); Catalyzes the biosynthesis of PGA (gamma-polyglutamic acid) from L-glutamate. Both the 44-kDa and the 33-kDa forms are required for PGA synthesis. | Glutamate dehydrogenase; Devoted to catabolic function of glutamate (and other amino acids of the glutamate family) utilization as sole nitrogen source. It is not involved in anabolic function of glutamate biosynthesis since B.subtilis possesses only one route of glutamate biosynthesis from ammonia, catalyzed by glutamate synthase. RocG is unable to utilize glutamate or glutamine as sole carbon source and to synthesize glutamate, but it is involved in the utilization of arginine, and proline as carbon or nitrogen source. The catabolic RocG is essential for controlling gltAB expression [...] | 0.485 |
capB | yrpC | BSU35900 | BSU26810 | Capsular polyglutamate synthetase (ATP-dependent amide ligase); Catalyzes the biosynthesis of PGA (gamma-polyglutamic acid) from L-glutamate. Both the 44-kDa and the 33-kDa forms are required for PGA synthesis. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.797 |
capC | capA | BSU35890 | BSU35880 | Capsular polyglutamate amide ligase/translocase subunit; Required for PGA (gamma-polyglutamic acid) biosynthesis. | Capsular polyglutamate synthetase; Seems to be required for maximum PGA (gamma-polyglutamic acid) production; Belongs to the CapA family. | 0.998 |
capC | capB | BSU35890 | BSU35900 | Capsular polyglutamate amide ligase/translocase subunit; Required for PGA (gamma-polyglutamic acid) biosynthesis. | Capsular polyglutamate synthetase (ATP-dependent amide ligase); Catalyzes the biosynthesis of PGA (gamma-polyglutamic acid) from L-glutamate. Both the 44-kDa and the 33-kDa forms are required for PGA synthesis. | 0.999 |
capC | capE | BSU35890 | BSU35870 | Capsular polyglutamate amide ligase/translocase subunit; Required for PGA (gamma-polyglutamic acid) biosynthesis. | Factor required for polyglutamate synthesis; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor. | 0.996 |
capC | comP | BSU35890 | BSU31690 | Capsular polyglutamate amide ligase/translocase subunit; Required for PGA (gamma-polyglutamic acid) biosynthesis. | Two-component sensor histidine kinase; Sensor in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Plays a role in sporulation, at least partly interchangeable with that of SpoIIJ. Probably activates ComA by phosphorylation. | 0.489 |
capC | degQ | BSU35890 | BSU31720 | Capsular polyglutamate amide ligase/translocase subunit; Required for PGA (gamma-polyglutamic acid) biosynthesis. | Pleiotropic regulator; Stimulates the phosphotransfer from phospho-DegS to DegU. Affects protease and levansucrose production. | 0.489 |
capC | degS | BSU35890 | BSU35500 | Capsular polyglutamate amide ligase/translocase subunit; Required for PGA (gamma-polyglutamic acid) biosynthesis. | Two-component sensor histidine kinase; Member of the two-component regulatory system DegS/DegU, which plays an important role in the transition growth phase. Involved in the control of expression of different cellular functions, including production of degradative enzymes such as the neutral and alkaline proteases, flagellum formation and biofilm formation. Acts as both a protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to DegU, and a protein phosphatase that dephosphorylates phospho-DegU. | 0.480 |