STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
alsRTranscriptional regulator controlling alsSD and ictEP expression (LysR family); Regulates the expression of the alsSD operon for acetoin biosynthesis. (302 aa)    
Predicted Functional Partners:
alsD
Alpha-acetolactate decarboxylase; Converts acetolactate into acetoin, which can be excreted by the cells. This may be a mechanism for controlling the internal pH of cells in the stationary stage; Belongs to the alpha-acetolactate decarboxylase family.
     
 0.951
alsS
Alpha-acetolactate synthase; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type e: enzyme.
     
 0.944
bdhA
Acetoin reductase/2,3-butanediol dehydrogenase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme.
      
 0.913
arfM
Transcriptional regulator; Activates, in anaerobic conditions, the transcription of the fermentative operons lctEP and alsDS, of the hmp gene encoding a flavohemoglobin-like protein, the nitrite reductase operon nasDE and the heme biosynthesis genes hemN and hemZ.
   
  
 0.838
resD
Two-component response regulator; Member of the two-component regulatory system ResD/ResE. Required for the expression of resA, ctaA, qcrABC and fnr; activation role in global regulation of aerobic and anaerobic respiration.
  
  
 0.510
glnK
Nitrogen-regulated PII-like regulator protein; Required for full induction of the nrgAB operon under conditions of ammonium limitation.
   
  
 0.506
fnr
Transcriptional regulator (FNR/CAP family); It is involved in the activation of genes necessary for anaerobic respiration.
   
  
 0.504
ywrK
Putative Na+/H+ antiporter; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt: putative transporter.
       0.438
acoR
Transcriptional regulator; Acts as a transcriptional activator of the acoABCL operon encoding the acetoin dehydrogenase complex.
      
 0.431
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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