STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ptkAProtein tyrosine kinase; May be involved in the regulation of capsular polysaccharide biosynthesis. Autophosphorylates in vitro. Phosphorylates and activates in vitro two UDP-glucose dehydrogenases, YwqF and TuaD, as well as the DNA-binding proteins Ssb and SsbB; Belongs to the CpsD/CapB family. (237 aa)    
Predicted Functional Partners:
ywqC
Modulator of YwqD protein tyrosine kinase activity; Required for YwqD kinase activity. May bring YwqD and its substrates into contact. Probably involved in the regulation of capsular polysaccharide biosynthesis.
 
 0.999
ywqE
Protein tyrosine-phosphatase; Dephosphorylates the phosphotyrosine-containing proteins YwqD, YwqF and Ssb.
  
 0.998
epsA
Modulator of protein tyrosine kinase EpsB; Evidence 2b: Function of strongly homologous gene; regulator.
  
 0.979
bscR
Transcriptional regulator for cypB; Negatively regulates the transcription of the fatR-cypB operon. Is displaced from its operator by a range of fatty acids such as oleate, linoleate and phytanate, thereby allowing transcription of the fatR-cypB operon.
      
 0.908
yjoA
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function.
   
  
 0.878
ywqF
UDP-glucose dehydrogenase; Catalyzes the conversion of UDP-glucose into UDP-glucuronate, one of the precursors of teichuronic acid. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
  
  
 0.869
yfkJ
Protein-tyrosine-phosphatase; Dephosphorylates the phosphotyrosine-containing proteins. Involved in ethanol stress resistance.
  
 
 0.863
salA
Mrp family regulator; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family.
    
 
 0.859
yabT
Putative serine/threonine-protein kinase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme.
    
 
 0.855
ybdM
Putative protein kinase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme.
    
 
 0.822
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.