node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
coiA | comEA | BSU11530 | BSU25590 | Protein involved in establishment of DNA transport in competence; Required for optimal transformation. | Membrane bound high-affinity DNA-binding receptor; Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect. | 0.871 |
coiA | comEC | BSU11530 | BSU25570 | Protein involved in establishment of DNA transport in competence; Required for optimal transformation. | DNA channel for uptake in competent cells; The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding; To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI. | 0.801 |
coiA | comFA | BSU11530 | BSU35470 | Protein involved in establishment of DNA transport in competence; Required for optimal transformation. | Helicase competence protein; Involved in transformation (competence for DNA uptake). Required for DNA uptake but not for binding. May provide the driving force for transport of DNA through an aqueous channel. Belongs to the helicase family. | 0.943 |
coiA | comGA | BSU11530 | BSU24730 | Protein involved in establishment of DNA transport in competence; Required for optimal transformation. | Membrane associated ATPase for DNA competence; Required for uptake of DNA by competent cells. | 0.846 |
coiA | dprA | BSU11530 | BSU16110 | Protein involved in establishment of DNA transport in competence; Required for optimal transformation. | DNA processing Smf single strand binding protein; Protein that helps load RecA onto ssDNA during transformation. Binds cooperatively to circular ssDNA, is able to bridge different segments of DNA. Favors the loading of RecA onto SsbA- or SsbB-coated ssDNA and formation of RecA-DNA filaments. RecA-ATP cannot catalyze homologous DNA strand exchange; SsbA and DprA activate strand exchange by RecA-ATP. | 0.956 |
coiA | recA | BSU11530 | BSU16940 | Protein involved in establishment of DNA transport in competence; Required for optimal transformation. | Multifunctional SOS repair factor; Multifunctional protein involved in homologous recombination, DNA repair and competence. Can catalyze the hydrolysis of (d)ATP in the presence of single-stranded DNA; prefers dATP at least in vitro, catalyzes the dATP-dependent uptake of single- stranded DNA by duplex DNA, and the dATP-dependent hybridization of homologous single-stranded DNAs (strand exchange). RecA-ATP cannot catalyze homologous DNA strand exchange; SsbA and DprA activate strand exchange by RecA-ATP. It interacts with LexA causing its activation and leading to its autocatalytic clea [...] | 0.844 |
coiA | ssbB | BSU11530 | BSU36310 | Protein involved in establishment of DNA transport in competence; Required for optimal transformation. | Single-strand DNA-binding protein; Not essential for replication of the chromosome, but is required for optimal competence. Binds ssDNA, binding is facilitated by DprA, acts as an accessory factor for homologous DNA strand exchange. | 0.981 |
comEA | coiA | BSU25590 | BSU11530 | Membrane bound high-affinity DNA-binding receptor; Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect. | Protein involved in establishment of DNA transport in competence; Required for optimal transformation. | 0.871 |
comEA | comEC | BSU25590 | BSU25570 | Membrane bound high-affinity DNA-binding receptor; Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect. | DNA channel for uptake in competent cells; The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding; To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI. | 0.999 |
comEA | comFA | BSU25590 | BSU35470 | Membrane bound high-affinity DNA-binding receptor; Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect. | Helicase competence protein; Involved in transformation (competence for DNA uptake). Required for DNA uptake but not for binding. May provide the driving force for transport of DNA through an aqueous channel. Belongs to the helicase family. | 0.998 |
comEA | comGA | BSU25590 | BSU24730 | Membrane bound high-affinity DNA-binding receptor; Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect. | Membrane associated ATPase for DNA competence; Required for uptake of DNA by competent cells. | 0.996 |
comEA | dprA | BSU25590 | BSU16110 | Membrane bound high-affinity DNA-binding receptor; Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect. | DNA processing Smf single strand binding protein; Protein that helps load RecA onto ssDNA during transformation. Binds cooperatively to circular ssDNA, is able to bridge different segments of DNA. Favors the loading of RecA onto SsbA- or SsbB-coated ssDNA and formation of RecA-DNA filaments. RecA-ATP cannot catalyze homologous DNA strand exchange; SsbA and DprA activate strand exchange by RecA-ATP. | 0.948 |
comEA | recA | BSU25590 | BSU16940 | Membrane bound high-affinity DNA-binding receptor; Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect. | Multifunctional SOS repair factor; Multifunctional protein involved in homologous recombination, DNA repair and competence. Can catalyze the hydrolysis of (d)ATP in the presence of single-stranded DNA; prefers dATP at least in vitro, catalyzes the dATP-dependent uptake of single- stranded DNA by duplex DNA, and the dATP-dependent hybridization of homologous single-stranded DNAs (strand exchange). RecA-ATP cannot catalyze homologous DNA strand exchange; SsbA and DprA activate strand exchange by RecA-ATP. It interacts with LexA causing its activation and leading to its autocatalytic clea [...] | 0.822 |
comEA | ssbB | BSU25590 | BSU36310 | Membrane bound high-affinity DNA-binding receptor; Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect. | Single-strand DNA-binding protein; Not essential for replication of the chromosome, but is required for optimal competence. Binds ssDNA, binding is facilitated by DprA, acts as an accessory factor for homologous DNA strand exchange. | 0.961 |
comEC | coiA | BSU25570 | BSU11530 | DNA channel for uptake in competent cells; The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding; To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI. | Protein involved in establishment of DNA transport in competence; Required for optimal transformation. | 0.801 |
comEC | comEA | BSU25570 | BSU25590 | DNA channel for uptake in competent cells; The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding; To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI. | Membrane bound high-affinity DNA-binding receptor; Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect. | 0.999 |
comEC | comFA | BSU25570 | BSU35470 | DNA channel for uptake in competent cells; The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding; To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI. | Helicase competence protein; Involved in transformation (competence for DNA uptake). Required for DNA uptake but not for binding. May provide the driving force for transport of DNA through an aqueous channel. Belongs to the helicase family. | 0.999 |
comEC | comGA | BSU25570 | BSU24730 | DNA channel for uptake in competent cells; The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding; To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI. | Membrane associated ATPase for DNA competence; Required for uptake of DNA by competent cells. | 0.990 |
comEC | dprA | BSU25570 | BSU16110 | DNA channel for uptake in competent cells; The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding; To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI. | DNA processing Smf single strand binding protein; Protein that helps load RecA onto ssDNA during transformation. Binds cooperatively to circular ssDNA, is able to bridge different segments of DNA. Favors the loading of RecA onto SsbA- or SsbB-coated ssDNA and formation of RecA-DNA filaments. RecA-ATP cannot catalyze homologous DNA strand exchange; SsbA and DprA activate strand exchange by RecA-ATP. | 0.988 |
comEC | recA | BSU25570 | BSU16940 | DNA channel for uptake in competent cells; The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding; To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI. | Multifunctional SOS repair factor; Multifunctional protein involved in homologous recombination, DNA repair and competence. Can catalyze the hydrolysis of (d)ATP in the presence of single-stranded DNA; prefers dATP at least in vitro, catalyzes the dATP-dependent uptake of single- stranded DNA by duplex DNA, and the dATP-dependent hybridization of homologous single-stranded DNAs (strand exchange). RecA-ATP cannot catalyze homologous DNA strand exchange; SsbA and DprA activate strand exchange by RecA-ATP. It interacts with LexA causing its activation and leading to its autocatalytic clea [...] | 0.926 |