STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ywpDPutative two-component sensor histidine kinase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative receptor. (278 aa)    
Predicted Functional Partners:
yclK
Two-component sensor histidine kinase [YclJ]; Could be member of the two-component regulatory system YclK/YclJ. Potentially phosphorylates YclJ.
 
    
 0.886
lytT
Two-component response regulator [LytS]; Member of the two-component regulatory system LytS/LytT that probably regulates genes involved in cell wall metabolism.
  
 0.857
natR
Two-component response regulator [NatK]; Member of the two-component regulatory system NatK/NatR that positively regulates the expression of the natAB operon. Acts by binding directly to the promoter of natAB.
 
  
 0.854
rbsB
Ribose ABC transporter (ribose-binding lipoprotein); Part of the ABC transporter complex RbsABC involved in ribose import. Binds ribose.
   
 
 0.713
phoR
Two-component sensor histidine kinase; Member of the two-component regulatory system PhoP/PhoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoP in response to environmental signals.
 
    
 0.693
resE
Two-component sensor histidine kinase; Member of the two-component regulatory system ResD/ResE involved in the global regulation of aerobic and anaerobic respiration. Probably phosphorylates ResD.
 
    
 0.417
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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