| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| amtB | glnA | BSU36510 | BSU17460 | Ammonium transporter; Functions as an ammonium and methylammonium transporter in the absence of glutamine. Required for ammonium utilization at low concentrations or at low pH values, when ammonium is the single nitrogen source. Required for binding of NrgB to the membrane. Interaction between GlnK-AmtB complex and TnrA protects TnrA from proteolytic degradation. | Glutamine synthetase; Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback-inhibited GlnA interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA- binding active state and turns on the transcription of genes required for nitrogen assimilation. Under condi [...] | 0.972 |
| amtB | glnK | BSU36510 | BSU36520 | Ammonium transporter; Functions as an ammonium and methylammonium transporter in the absence of glutamine. Required for ammonium utilization at low concentrations or at low pH values, when ammonium is the single nitrogen source. Required for binding of NrgB to the membrane. Interaction between GlnK-AmtB complex and TnrA protects TnrA from proteolytic degradation. | Nitrogen-regulated PII-like regulator protein; Required for full induction of the nrgAB operon under conditions of ammonium limitation. | 0.999 |
| amtB | glnR | BSU36510 | BSU17450 | Ammonium transporter; Functions as an ammonium and methylammonium transporter in the absence of glutamine. Required for ammonium utilization at low concentrations or at low pH values, when ammonium is the single nitrogen source. Required for binding of NrgB to the membrane. Interaction between GlnK-AmtB complex and TnrA protects TnrA from proteolytic degradation. | Transcriptional regulator (nitrogen metabolism); Transcription repressor that represses many genes including ureABC and tnrA, during nitrogen excess. On the contrary of the MerR members, which require longer DNA sites for high-affinity binding, GlnR requires a DNA sequence of 17 nucleotides as minimal binding site. | 0.907 |
| amtB | gltA | BSU36510 | BSU18450 | Ammonium transporter; Functions as an ammonium and methylammonium transporter in the absence of glutamine. Required for ammonium utilization at low concentrations or at low pH values, when ammonium is the single nitrogen source. Required for binding of NrgB to the membrane. Interaction between GlnK-AmtB complex and TnrA protects TnrA from proteolytic degradation. | Glutamate synthase (large subunit); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the glutamate synthase family. | 0.894 |
| amtB | gltB | BSU36510 | BSU18440 | Ammonium transporter; Functions as an ammonium and methylammonium transporter in the absence of glutamine. Required for ammonium utilization at low concentrations or at low pH values, when ammonium is the single nitrogen source. Required for binding of NrgB to the membrane. Interaction between GlnK-AmtB complex and TnrA protects TnrA from proteolytic degradation. | Glutamate synthase (small subunit); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. | 0.759 |
| amtB | nasA | BSU36510 | BSU03330 | Ammonium transporter; Functions as an ammonium and methylammonium transporter in the absence of glutamine. Required for ammonium utilization at low concentrations or at low pH values, when ammonium is the single nitrogen source. Required for binding of NrgB to the membrane. Interaction between GlnK-AmtB complex and TnrA protects TnrA from proteolytic degradation. | Putative nitrate transporter; May function as a nitrate transporter. | 0.860 |
| amtB | nasD | BSU36510 | BSU03300 | Ammonium transporter; Functions as an ammonium and methylammonium transporter in the absence of glutamine. Required for ammonium utilization at low concentrations or at low pH values, when ammonium is the single nitrogen source. Required for binding of NrgB to the membrane. Interaction between GlnK-AmtB complex and TnrA protects TnrA from proteolytic degradation. | Assimilatory nitrite reductase subunit; Required for nitrite assimilation. | 0.898 |
| amtB | tnrA | BSU36510 | BSU13310 | Ammonium transporter; Functions as an ammonium and methylammonium transporter in the absence of glutamine. Required for ammonium utilization at low concentrations or at low pH values, when ammonium is the single nitrogen source. Required for binding of NrgB to the membrane. Interaction between GlnK-AmtB complex and TnrA protects TnrA from proteolytic degradation. | Nitrogen sensing transcriptional regulator; Transcription regulator that actives the transcription of genes required for nitrogen assimilation such as nrgAB (ammonium transport), nasABCDEF (nitrate/nitrite assimilation), ureABC (urea degradation) and gabP (GABA transport), during nitrogen limitation. Also represses glnRA and gltAB in the absence of ammonium. On the contrary of the MerR members, which require longer DNA sites for high-affinity binding, TnrA requires a DNA sequence of 17 nucleotides as minimal binding site. | 0.937 |
| amtB | yhcK | BSU36510 | BSU09120 | Ammonium transporter; Functions as an ammonium and methylammonium transporter in the absence of glutamine. Required for ammonium utilization at low concentrations or at low pH values, when ammonium is the single nitrogen source. Required for binding of NrgB to the membrane. Interaction between GlnK-AmtB complex and TnrA protects TnrA from proteolytic degradation. | Putative diguanylate cyclase or phosphodiesterase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. | 0.778 |
| amtB | ykoW | BSU36510 | BSU13420 | Ammonium transporter; Functions as an ammonium and methylammonium transporter in the absence of glutamine. Required for ammonium utilization at low concentrations or at low pH values, when ammonium is the single nitrogen source. Required for binding of NrgB to the membrane. Interaction between GlnK-AmtB complex and TnrA protects TnrA from proteolytic degradation. | Putative sensor diguanylate cyclase; Probable signaling protein whose physiological role is not yet known. | 0.880 |
| glnA | amtB | BSU17460 | BSU36510 | Glutamine synthetase; Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback-inhibited GlnA interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA- binding active state and turns on the transcription of genes required for nitrogen assimilation. Under condi [...] | Ammonium transporter; Functions as an ammonium and methylammonium transporter in the absence of glutamine. Required for ammonium utilization at low concentrations or at low pH values, when ammonium is the single nitrogen source. Required for binding of NrgB to the membrane. Interaction between GlnK-AmtB complex and TnrA protects TnrA from proteolytic degradation. | 0.972 |
| glnA | glnK | BSU17460 | BSU36520 | Glutamine synthetase; Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback-inhibited GlnA interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA- binding active state and turns on the transcription of genes required for nitrogen assimilation. Under condi [...] | Nitrogen-regulated PII-like regulator protein; Required for full induction of the nrgAB operon under conditions of ammonium limitation. | 0.711 |
| glnA | glnR | BSU17460 | BSU17450 | Glutamine synthetase; Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback-inhibited GlnA interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA- binding active state and turns on the transcription of genes required for nitrogen assimilation. Under condi [...] | Transcriptional regulator (nitrogen metabolism); Transcription repressor that represses many genes including ureABC and tnrA, during nitrogen excess. On the contrary of the MerR members, which require longer DNA sites for high-affinity binding, GlnR requires a DNA sequence of 17 nucleotides as minimal binding site. | 0.999 |
| glnA | gltA | BSU17460 | BSU18450 | Glutamine synthetase; Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback-inhibited GlnA interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA- binding active state and turns on the transcription of genes required for nitrogen assimilation. Under condi [...] | Glutamate synthase (large subunit); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the glutamate synthase family. | 0.988 |
| glnA | gltB | BSU17460 | BSU18440 | Glutamine synthetase; Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback-inhibited GlnA interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA- binding active state and turns on the transcription of genes required for nitrogen assimilation. Under condi [...] | Glutamate synthase (small subunit); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. | 0.986 |
| glnA | nasD | BSU17460 | BSU03300 | Glutamine synthetase; Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback-inhibited GlnA interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA- binding active state and turns on the transcription of genes required for nitrogen assimilation. Under condi [...] | Assimilatory nitrite reductase subunit; Required for nitrite assimilation. | 0.975 |
| glnA | tnrA | BSU17460 | BSU13310 | Glutamine synthetase; Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback-inhibited GlnA interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA- binding active state and turns on the transcription of genes required for nitrogen assimilation. Under condi [...] | Nitrogen sensing transcriptional regulator; Transcription regulator that actives the transcription of genes required for nitrogen assimilation such as nrgAB (ammonium transport), nasABCDEF (nitrate/nitrite assimilation), ureABC (urea degradation) and gabP (GABA transport), during nitrogen limitation. Also represses glnRA and gltAB in the absence of ammonium. On the contrary of the MerR members, which require longer DNA sites for high-affinity binding, TnrA requires a DNA sequence of 17 nucleotides as minimal binding site. | 0.996 |
| glnK | amtB | BSU36520 | BSU36510 | Nitrogen-regulated PII-like regulator protein; Required for full induction of the nrgAB operon under conditions of ammonium limitation. | Ammonium transporter; Functions as an ammonium and methylammonium transporter in the absence of glutamine. Required for ammonium utilization at low concentrations or at low pH values, when ammonium is the single nitrogen source. Required for binding of NrgB to the membrane. Interaction between GlnK-AmtB complex and TnrA protects TnrA from proteolytic degradation. | 0.999 |
| glnK | glnA | BSU36520 | BSU17460 | Nitrogen-regulated PII-like regulator protein; Required for full induction of the nrgAB operon under conditions of ammonium limitation. | Glutamine synthetase; Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback-inhibited GlnA interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA- binding active state and turns on the transcription of genes required for nitrogen assimilation. Under condi [...] | 0.711 |
| glnK | gltA | BSU36520 | BSU18450 | Nitrogen-regulated PII-like regulator protein; Required for full induction of the nrgAB operon under conditions of ammonium limitation. | Glutamate synthase (large subunit); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the glutamate synthase family. | 0.761 |
